Hey1-NCOA2是间充质软骨肉瘤中一种特殊的复发性易位。由此产生的嵌合转录因子包括Hey1 DNA结合域(外显子1-4)和两个激活域以及一个来自ncoa2(外显子13-23)的组蛋白甲基转移酶相互作用域。HEY1-NCOA2 is a specific and recurrent translocation in mesenchymal chondrosarcoma. The resulting chimeric transcription...
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您好，很高兴为您解答。这个是HEY1-NCOA2融合基因，在正常的人体细胞中，HEY1基因位置在8号染色体的q13.3，NCOA2基因的位置在8号染色体的q21.13，这两个基因隔很远，并不连续：在间叶软骨肉瘤中，这两个基因融合到一起了，形成了HEY1-NCOA2融合基因，会使肿瘤细胞过度生长且不易死亡。希望能帮到...
To functionally characterize the fusion in MCS tumorigenesis, we generated stably transduced iPSC-derived mesenchymal stem cells (iPSC-MSC) with inducible expression of HEY1::NCOA2. We previously demonstrated that the expression of HEY1::NCOA2 significantly enhanced cell proliferation, upregulated PDGF...
mesenchymal chondrosarcomadoi:10.1111/ped.12407John Wiley & Sons, LtdPediatrics InternationalMoriya K, Katayama S, Onuma M, Rikiishi T, Hosaka M, Watanabe M, et al. Mesenchymal chondrosarcoma diagnosed on FISH for HEY1-NCOA2 fusion gene. Pediatr Int 2014;56:e55-7....
In addition to the non-typical pathological finding, the correct diagnosis was hampered by the poor RNA quality of the surgical specimens and non-specific STAT6 nuclear staining.ConclusionThis is the first reported case of intracranial MCS with an alternative HEY1::NCOA2 ...
Genetically, this tumor is mainly characterized by the recurrent HEY1-NCOA2 fusion. Localized tumor is managed surgically; traditional chemotherapy and radiation therapy, however, did not appear to substantially improve the event-free survival rate of mesenchymal chondrosarcoma patients. It is clear ...
Imatinib, as well as specific inhibitors of ABL and PDGFR, demonstrated a highly selective cytotoxic effect targeting the HEY1-NCoA2 fusion-driven cellular model. In addition, patient-derived xenograft (PDX) models of MCS harboring the HEY1-NCoA2 fusion were developed from a primary tumor and ...
The identification of a biphasic morphology in pleural effusion, along with detection of the HEY1::NCOA2 fusion using next-generation sequencing, serve as vital indicators for an accurate diagnosis.doi:10.1111/cyt.13296Jingmin ZhongQingjie Wang...
Mesenchymal chondrosarcoma (MC) is a rare but extremely aggressive type of chondrosarcoma distinguished by the presence of both primitive mesenchymal cells and fully developed chondroid tissue. The identification of a biphasic morphology in pleural effusion, along with detection of the HEY1 :: NCOA2 ...