Hexose-6-phosphate dehydrogenase (H6PD) is a luminal enzyme of the endoplasmic reticulum that is distinguished from cytosolic glucose-6-phosphate dehydrogenase by several features. H6PD converts glucose-6-phosphate and NADP+ to 6-phosphogluconate and NADPH, thereby catalyzing the first two reactions ...
4. 4. The results demonstrated that H6PD and G6PD share at least one antigenic determinant in common, thus providing evidence for our prediction that the two enzymes have diverged from a common ancestral molecule. 展开 关键词: G6PD, glucose 6-phosphate dehydrogenase H6PD, hexose 6-phosphate ...
H6PD, CT (H6PD, GDH, GDH/6PGL endoplasmic bifunctional protein, Glucose 1-dehydrogenase, Hexose-6-phosphate dehydrogenase, 6-phosphogluconolactonase)供应商 MyBioSource产品货号 MBS644912产品报价 ￥询价/0.2mL ￥询价/5x0.2mL ￥询价/其它规格产品说明书 点击查看购买...
Hexose-6-phosphate dehydrogenase (H6PD) is the main NADPH generating enzyme in the lumen of the endoplasmic reticulum. H6PD is regarded as an ancillary enzyme in prereceptorial glucocorticoid activation and probably acts as a nutrient sensor and as a prosurvival factor. H6PD expression was ...
Hexose-6-phosphate dehydrogenase (H6PD) is thought to be the major source of NADPH within the endoplasmic reticulum (ER), determining 11 beta-hydroxysteroid dehydrogenase 1 (11 beta-HSD1) reaction direction to convert inert 11-oxo- to potent 11 beta-hydroxyglucocorticoids. Here, we tested the ...
Using the published protein sequence from a rabbit microsomal glucose-6-phosphate dehydrogenase G6PD we have isolated and sequenced a cDNA clone coding for its human equivalent, which is also known as hexose-6-phosphate dehydrogenase (H6PD) and glucose dehydrogenase. The corresponding genomic sequence...
endoplasmic reticulumNADPHsignalingHexose-6-phosphate dehydrogenase (H6PD) produces rdoi:10.1096/fj.201700870RRTsachakiUnivMariaUnivMladenovicUnivNatasaUnivStambergovaUnivHanaUnivBirkUnivJuliaUnivOdermattUnivAlexUnivThe FASEB Journal
Inheritance of hexose 6-phosphate dehydrogenase polymorphism in brook troutElectrophoretic analysis reveals two alleles, Hpd Juicey,s-1 , for the H6PD gene in brook trout from Newfoundland, with the Hpd Banff-1 allele predominant. In contrast, the population from Brotkork Lake, Quebec, possesses ...
Hexose-6-phosphate dehydrogenase (H6PD) catalyzes the first two steps of the pentose-phosphate pathway (PPP) within the endoplasmic reticulum (ER), generating the redox equivalent NADPH. It has been shown that mice lacking H6PD develop defects mainly in skeletal muscles [1]. Nevertheless, the ...
We have proposed that this NADPH is generated within the endoplasmic reticulum by the enzyme hexose-6-phosphate dehydrogenase. To address this hypothesis, we generated mice with a targeted inactivation of the H6PD gene. These mice were unable to convert 11-dehydrocorticosterone (11-DHC) to ...