and possible effects on the immune system (Ecobichon, 1996). It is commonly present in fat because of itslipophilicityand tendency to bioaccumulate (Meset al.,1982). The adverse reproductive effects of HCB have been reported in rats, minks, ferrets, and monkeys (Bleavinset al.,1984;Iatropo...
Chronic exposure of humans to HCB leads to a number of effects, such as triggering of porphyria, microsomal enzyme induction, thyroid dysfunctions, neurological symptoms, and immunological disorders. In animals, HCB induced hepatic porphyria, neurotoxic effects, and toxic effects on the thyroid ...
Based on the sufficient weight of evidence of carcinogenicity of hexachlorobenzene in several studies in rodents following long‐term exposure, the compound has been classified as “probably carcinogenic to humans”. Based on comparison of the average daily intake of hexachlorobenzene by the Canadian ...
The occurrence of HCB in humans, food, wild mammals, birds, fish, and soil is described. Results of numerous experiments concerning HCB toxicity to rats, rabbits, guinea pigs, mice, hamsters, monkeys, dogs, sheep, birds, and pigs are examined. Multigeneration and teratology studies concerning ...
Adverse Effects Hepatotoxin Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion Reproductive Toxin Yes IARC Carcinogen Possible (2b) NTP Carcinogen Anticipated human carcinogen ACGIH Carcinogen Confirmed Animal Other Poison Organochlorine Diseas...
Health effects of chronic high exposure to hexachlorobenzene in a general population sample. Hexachlorobenzene, an organochlorine compound that accumulates in humans, is widespread throughout the environment. In this study, we describe the health s... M Sala,J Sunyer,R Otero,... - 《Archives of...
Chronic exposure of humans to HCB produces a number of effects, such as triggering of porphyria, increased synthesis of liver microsomal enzymes, neurological symptoms, immunological disorders and thyroid dysfunctions. In rats, HCB induced hepatic porphyria, neurotoxic effects, and toxic effects on the...
HCB is readily absorbed by both humans and animals. Whilst acute toxicity is low, medium and long-term exposures have been associated with a number of negative health effects. The liver is one major target organ, with porphyria and the induction of cytochrome P-450 enzymes appearing as the pr...
Data from an epidemic reported in Turkey (1955-1959) is the only information about the relationship between hexachlorobenzene (HCB) intake and porphyria cutanea tarda in humans. No information is available on the HCB threshold exposure level to induce porphyria cutanea tarda.To study HCB serum ...
Although HCB is one of the most common organochlorine compound in humans, little investigation on its health effects has been done. Polychlorobiphenyls (PCBs) are also widespread toxic environmental contaminants. The aim of the present study was to investigate the association of serum HCB and PCB ...