Mesenteric vein thrombosis Prothrombin gene Factor Ⅴ Leiden Heterozygous Anticoagulation Oral contraceptivesMesenteric venous thrombosis(MVT)is a rare but life threatening form of bowel ischemia.It is implicated in 6%-9% of all cases of acute mesenteric ischemia.The proportion of patients with primary(...
The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus. OBJECTIVE: We sought to estimate the frequency of pregnancy-related thromboembolic events among carriers of the factor V Leiden (FVL) mutation without a pe... D Dizon-Townson,C Miller,B Sibai,... ...
Activated protein C resistance, caused by a point mutation factor V gene was described in last decade. This article highlights a case of a 9 year-old-boy who admitted to Ba艧kent University Hospital with right- sided hemiplegia. He was diagnosed as heterozygous for the FVL muta- tion and ...
The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Impro... The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation...
It is well documented that factor V Leiden mutation (FVL) is a common hypercoagulable risk factor in the Caucasian population. Patients with homozygous FVL mutation have an increased risk for venous thromboembolism. However, there have been few cases of heterozygous FVL mutation associated with ...
ABO blood group genotypes and the risk of venous thrombosis: effect of factor V Leiden Among the 471 patients, 92 (19.5%) carried factor (F)V Leiden compared with 14 (3.0%) of the 471 controls, yielding an OR for venous thrombosis of 7.9 (95%... VM Morelli,MCHD Visser,HL Vos,......
Combined oral contraceptives and factor V Leiden mutation are multiplicative risk factors for venous thromboembolism. However, it remains unknown whether this multiplicative effect is reflected in thrombin generation assays. We report here the evolution of the thrombin generation profile while taking ...
Summary Background The high allelic frequency of the prothrombotic Leiden polymorphism in human blood coagulation factor V (FV) has been speculated to reflect positive selection during evolution. Heterozygous Leiden carriers enrolled in the placebo arm of the PROWESS sepsis trial and heterozygous Leiden ...
Genetic analysis revealed that he was heterozygous for the prothrombin Factor V (FV) Leiden and MTHFR C677T mutations. Therapy started with intravenous heparin, followed by warfarin. He had no other episodes over a 2-year follow-up. Lifelong oral anticoagulant therapy was recommended. 展开 ...
Inherited thrombophilia is now demonstrated to be a multigenic disease; the most common genetic risk factors are the factor V Leiden and the prothrombin mutations. Prior to the discovery of these mutations, three less common genetic risk factors had been......