Heterozygous factor V Leiden mutation manifesting with combined central retinal vein occlusion, cilioretinal artery occlusion, branch retinal artery occlusion, and anterior ischaemic optic neuropathy: a case reportCentral retinal vein occlusionCilioretinal artery occlusion...
Activated protein C resistance, caused by a point mutation factor V gene was described in last decade. This article highlights a case of a 9 year-old-boy who admitted to Ba艧kent University Hospital with right- sided hemiplegia. He was diagnosed as heterozygous for the FVL muta- tion and ...
BACKGROUND: Factor V Leiden mutation represents the most common genetic risk factor of venous thrombosis in Caucasian population. A common mutation in prothrombin gene, which is due to G-->A transition at position 20210, is also associated with elevated prothrombin concentration and thrombosis. Both...
Of a person carrying different genes at the same gene locus in corresponding chromosomes. TheALLELESare different. A singleDOMINANTgene can manifest itself in a heterozygous person. Recessive genes are only manifest if both are present (HOMOZYGOUS). ...
We report here the evolution of the thrombin generation profile while taking combined oral contraceptives and after their discontinuation in a woman with heterozygous factor V Leiden mutation. The proband exhibited a distinctly prothrombotic thrombin generation profile including markedly decreased thrombomodulin...
Objective: The factor V Leiden (FVL) mutation (Arg506Glu) results in the production of a FV protein that when activated, is relatively resistant to inactiv... S Schoenmakers,A Groot 被引量: 0发表: 2008年 加载更多来源期刊 Journal of Thrombosis & Haemostasis Jth 2015/7/19 12:37:00 研究...
The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus. OBJECTIVE: We sought to estimate the frequency of pregnancy-related thromboembolic events among carriers of the factor V Leiden (FVL) mutation without a pe... D Dizon-Townson,C Miller,B Sibai,... ...
It is well documented that factor V Leiden mutation (FVL) is a common hypercoagulable risk factor in the Caucasian population. Patients with homozygous FVL mutation have an increased risk for venous thromboembolism. However, there have been few cases of heterozygous FVL mutation associated with ...
The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Impro... The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation...
Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia Sepsis is associated with systemic inflammation, coagulopathy, and disrupted protein C (PC) pathway function. The effect of prothrombotic polymorphism, fac... B Kerlin - 《...