Therapeutic vaccine fights herpes.Reports on a new therapeutic vaccine which reduces the frequency with which genital sores appear in patients infected with the herpesvirus. Article in the June 11, 1994 issue of 'Lancet'; Work of Stephen E. Straus and others.AdlerT.Science News...
[11] Agenus announces positive phase II study results of HerpV therapeutic vaccine to treat patients with herpes simplex virus-2. Lexington, Massachusetts, Monday, November 11, 2013. [13] Kim HC, Lee HK. Vaccines against Genital Herpes: Where Are We? Vaccines (Basel). 2020 Jul 27;8(3):...
Childhood HSE can therefore be sporadic but genetic, enabling new diagnostic and therapeutic approaches. In this Review, we examine essential cellular and molecular mechanisms of cell-intrinsic antiviral immunity in the brain that are disrupted in individuals with HSE. These mechanisms include both ...
Therefore, there is an urgent need for development of new topical therapeutic platforms enabling efficient antiviral therapy. View article Herpesviruses Christopher J. Burrell, ... Frederick A. Murphy, in Fenner and White's Medical Virology (Fifth Edition), 2017 Genital Herpes Most primary genital ...
viral loads and genital shedding in both women93–96and men.97It is plausible that higher dosages of existing98or new and more efficacious antiherpetic drugs such as helicase-primase inhibitors99or an effective therapeutic HSV-2 vaccine100would be required to have any notable impact on HSV-2 ...
(3 serotypes × 2 meganucleases). Clinical translation of such a complex regimen could raise manufacturing and quality control issues. We therefore sought to simplify AAV/meganuclease therapy to reduce the complexity of our therapeutic regimen. We took advantage of the dual cutting meganuclease ...
“NanoBio’s intranasal vaccine is one of the only vaccine candidates we’ve studies that has shown efficacy in both the prophylactic and the therapeutic animal models,” Investigator Dr David Bernstein, professor of pediatrics at Cincinnati Children’s Hospital Medical Center, said in the release....
- 《Vaccine》 被引量: 0发表: 2024年 Practice Patterns in the Initial Management of Herpes Zoster Ophthalmicus in the United States Purpose: The aims of this study were to examine the trends in the initial management of herpes zoster ophthalmicus (HZO) in the United States from 2010 to .....
1998. Therapeutic periocular vaccination with a subunit vaccine induces higher levels of herpes simplex virus-specific tear secretory immunoglobulin A than systemic vaccination and provides protection against recurrent spon- taneous ocular shedding of virus in latently infected rabbits. Virology 252: 200-...
Herpes simplex virus type 1 (HSV-1) is a neurotropic DNA virus with many favorable properties both as a delivery vector for cancer therapeutic genes and as a backbone for oncolytic viruses. Herpes simplex virus type 1 is highly infectious, so HSV-1 vectors are efficient vehicles for the ...