Herpes simplex virus type 1 (HSV-1) is human specific virus. The intercellular transmission of HSV-1 is essential in its pathogenesis. The tunneling nanotube (TNT), a new mode connecting distant cells, has been found to play an important role in the spread of...
Synchronized infection resulted in high cell-to-cell variability of both transcripts that was independent of the virus load and present throughout the infection (Fig. 1c and Supplementary 1a). In agreement with their expression kinetics, UL29 transcript counts were higher at each time point and ...
Neonatal Herpes Simplex Virus (HSV) infection is a serious illness with significant mortality and morbidity for disseminated disease. Clinical diagnosis of neonatal HSV infection is often difficult without evidence of HSV exposure, for example, absence of a rash or the presence of non-specified manife...
Genital herpesis a disease caused by the herpes simplex virus (HSV), of which there are two types. Type 1 (HSV-1) usually causesoral herpes, an infection of the lips and mouth. Symptoms are commonly known as cold sores or fever blisters. In the past, HSV-1 was not known to cause g...
THERE are clearly two levels at which the immune response may intervene to induce protection against viral infection. Neutralising antibodies effectively limit spread of free virus in many situations, thus preventing reinfection. In a number of viral diseases, however, it is often not possible to cu...
The sequential activation of immediate early (IE), early (E) and late (L) genes is required to allow productive herpes simplex virus type 1 (HSV-1) infection. Several evidences suggest that, together with inflammation, an immunological response incapable to counteract HSV-1 reactivation plays a...
Previous studies have reported that the IRE1/XBP1 pathway is inhibited upon herpes simplex virus 1 (HSV-1) infection; however, the underlying molecular mechanism is still elusive. Here, we uncovered a role of the HSV-1 UL41 protein in inhibiting the IRE1/XBP1 signal pathway. Ectopic ...
The glycoproteins of herpes simplex virus type 1 (HSV-1) are important targets for the immune system in the control of HSV-1 infections. The humoral and T cell responses to the glycoprotein (g)H-t(His):gL complex of HSV-1 were studied in seven HSV-1-seropositive and three HSV-1-sero...
Herpes Simplex Virus 产品及特点: 荧光定量PCR法检测的是来SYBR Green掺入到双链DNA中的量。SYBR Green掺入到双链DNA中后会发出荧光。但是只要是双链,它都掺。 而探针自法是当探针结合到目标序列上以百后,聚合酶降解探针后,探针上自带的荧光基团离开淬灭基团,从而发度出荧光。
Infection by viruses, including herpes simplex virus-1 (HSV-1), and cellular stresses cause widespread disruption of transcription termination (DoTT) of RNA polymerase II (RNAPII) in host genes. However, the underlying mechanisms remain unclear. Here, we demonstrate that the HSV-1 immediate early...