Drug-Drug InteractionRepaglinide KmRepaglinide Bioanalytical MethodRepaglinide is type 2 short acting anti-diabetic drug which is primarily metabolized by CYP2C8 and CYP3A4 and is also a substrate of influx transporter OATP1B1. HIV drugs are potent inhibitors of CYP3A4 and OATP transporters. ...
In recent years, the issue of herbal medicine-drug interactions has generated significant concern. Such interactions can increase the risk for an individual patient, especially with regard to drugs with a narrow therapeutic index (e.g. warfarin, ciclosporin and digoxin). The present article summarize...
Heredi-Szabo K, Palm JE, Andersson TB, Pal A, Mehn D, Fekete Z, Beery E, Jakab KT, Jani M, Krajcsi P (2013) A P-gp vesicular transport inhibition assay - optimization and validation for drug-drug interaction testing. Eur J Pharm Sci 49:773–781. https://doi.org/10.1016/j.ejps...
Until reports of interactions between St John's wort and drugs such as digoxin, warfarin, protease inhibitors and oral contraceptives began to appear, very few herb-drug interactions were documented. These are now becoming more common, although still rare compared with drug-drug interactions. In th...
Based on herb–drug interactions, three herb–drug interaction groups were formed: DS-drug, CX-drug, and DS-CX-drug. In every group, three datasets were formed. As mentioned in the method section, to verify whether the extra structural similarity analysis and target interactions can help improv...
HS-23, an extract of the dried flower buds of Lonicera japonica , is a new botanical drug currently being evaluated in a phase I clinical study in Korea for the treatment of sepsis. The in vitro induction and inhibition potentials of HS-23 on the drug-metabolizing enzymes using human hepato...
Herbal drug loaded poly(D,L-lactide-co-glycolide) ultrafine fibers: Interaction with pathogenic bacteria 来自 Springer 喜欢 0 阅读量: 29 作者:HM Al-Youssef,M Amina,S Hassan,T Amna…摘要: This study investigated for the first time the antimicrobial effect of methanolic extract of Grewia mollis ...
Stockley's Herbal Medicines Interactions is now in its second edition and remains a unique collaboration between a team of experts in the fields of drug interactions, clinical herbal medicines, phytopharmacovigilance and regulation of herbal medicinal products. It provides an invaluable reference text fo...
Pharmacokinetic herb-drug interaction between ginger and crizotinib. Br J Clin Pharmacol. 2020;86(9):1892-1893.30701569 107. Zhang W, Lim LY. Effects of spice constituents on P-glycoprotein-mediated transport and CYP3A4-mediated metabolism in vitro. Drug Metab Dispos. 2008;36(7):1283-...
Based on herb–drug interactions, three herb–drug interaction groups were formed: DS-drug, CX-drug, and DS-CX-drug. In every group, three datasets were formed. As mentioned in the method section, to verify whether the extra structural similarity analysis and target interactions can help improv...