If yourbreast cancerhas a significant number of receptors for either estrogen or progesterone, it’s considered hormone-receptor positive. Tumors that are ER/PR-positive are much more likely to respond to hormone therapy than tumors that are ER/PR-negative. ...
HER2-positive (HER2+) metastatic breast cancer (mBC) is highly aggressive and a major threat to human health. Despite the significant improvement in patients’ prognosis given the drug development efforts during the past several decades, many clinical questions still remain to be addressed such as ...
including trastuzumab-deruxtecan, which has come out in the last two or three years. And it really has changed the trajectory of metastatic HER2-positive breast cancer. And also, there are two tyrosine kinase inhibitors...
I think the most important advances for HER2-positive advanced breast cancer have really been the antibody drug conjugates, including trastuzumab-deruxtecan, which has come out in the last two or three years. And it really has changed the trajectory of metastatic HER2-positive breast cancer. And...
If there is a group where surveillance might be helpful, whether it's improving survival or preventing symptoms, it does feel like the HER2-positive group might be the sweet spot where that would be useful. But I won't be doing it until you show me data that it works....
You may find it helpful to ask your doctor the following questions to learn more about your HER2 test results and what they mean for your health: What are the results of my HER2 test? Am I HER2-positive or HER2-negative? What does the result of my test mean for my prognosis?
HER2-amplicon Breast cancer HER2 positive siRNA Trastuzumab Lapatinib Drug resistance 17q12 Gene silencing Functional screen 1. Introduction Breast cancer is a heterogeneous disease with several different sub-diseases with differences in tumor biology, histopathology and prognosis (Perou et al., 2000; Rus...
It can either positively or negatively regulate cell proliferation. For example, contrary to the positive regulation of cell proliferation that is more commonly observed, MLL was shown to negatively regulate pancreatic neuroendocrine cell proliferation. In this context MLL interacts with the tumor ...
(bystereoscope)proportion values. For every sample, we multiplied the paired proportion values for each subset in each spot, and then applied a z-transformation (subtraction by the mean followed by division with the standard deviation). High positive signals indicate the increased joint presence, ...
EP: 2.Patients Prefer Subcutaneous Regimen for HER2-Positive Breast Cancer EP: 3.Subcutaneous Regimen Shows Non-Inferiority for HER2+ Breast Cancer EP: 4.Pharmacokinetics of Subcutaneous HER2 Therapy Noninferior in BC EP: 5.Advantages of SC HER2 Therapy Over IV Administration in Breast Cancer...