including trastuzumab-deruxtecan, which has come out in the last two or three years. And it really has changed the trajectory of metastatic HER2-positive breast cancer. And also, there are two tyrosine kinase inhibitors...
From ABC6 to ABC7, what do you think is the most important progress in the treatment of HER2-positive advanced breast cancer? Sandra M. Swain 教授 CLEOPATRA研究PI 我认为抗体偶联药物(ADC)是HER2阳性晚期乳腺癌治疗领域中最重要的成就,尤其是在过去两三年中研发的德曲妥珠单抗。这一重大进展从本质上改...
About 20–25% of patients with invasive breast cancer are HER2-positive and it is considered as an independent risk factor for recurrence and metastasis.8Large number of data shows that trastuzumab combined with chemotherapy can reduce nearly 50% RR of recurrence and metastasis.177In the adjuvant ...
Alvaro Moreno-Aspitia11, Martine Piccart10, Marianne Paesmans3, Evandro de Azambuja 1 and Matteo Lambertini 16,17 ✉ 8, The prognostic performance of PREDICT in patients with HER2-positive early breast cancer (EBC) treated in the modern era with effective chemotherapy and anti-HER2 targeted ...
Alvaro Moreno-Aspitia11, Martine Piccart10, Marianne Paesmans3, Evandro de Azambuja 1 and Matteo Lambertini 16,17 ✉ 8, The prognostic performance of PREDICT in patients with HER2-positive early breast cancer (EBC) treated in the modern era with effective chemotherapy and anti-HER2 targeted ...
What are the key features of the A Her2 Specific Macrophage Biomimetic Nanoplatform Ir820@zif 8@em (AMBP) nanoplatform developed for Human Epidermal Growth Factor Receptor2 (HER2) positive breast cancer treatment? How does the A Her2 Specific Macrophage Biomimetic Nanoplatform Ir820@zif 8@em (AMBP...
None of the cases carrying a positive driver gene mutation showed Her2 overexpression. Regarding the small subset of patients (10 patients) submitted for CGP mutational analysis, 6 were males, and four were females with a mean age of 60.1 (range 25–88 years). Regarding their smoking history,...
Abstract Sequential endocrine therapy (ET) is recommended for postmenopausal women with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) metastatic breast cancer (mBC) and without visceral symp- toms. Chemotherapy (CT) can be ...
“It’s exciting that we finally have an approval for something in this cohort of patients [with HER2-positive CRC]. We have had number of phase 2 trials that have shown benefit for small molecules, antibody-drug conjugates [ADCs], and antibodies targeting HER2, but nothing had been ap...
(bystereoscope)proportion values. For every sample, we multiplied the paired proportion values for each subset in each spot, and then applied a z-transformation (subtraction by the mean followed by division with the standard deviation). High positive signals indicate the increased joint presence, ...