Herceptin is approved in adults, in combination with chemotherapy (cisplatin and either capecitabine or 5-fluorouracil), for the treatment of HER2-positive metastatic cancer of the stomach or gastroesophageal junction (where the esophagus meets the stomach) in patients who have not received prior treat...
6 Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial[J]. Lancet. 2010 Aug 28;376...
It is expected that more anti-HER2 drugs will be developed and introduced into clinical practice to treat HER2-positive cancers, including gastric cancer. 展开 关键词: Stomach neoplasms Trastuzumab Receptor erbB-2 HER-2 proto-oncogene protein ...
9. NCCN Guidelines for Patients. Stomach Cancer,2021. 10. Mitani S, Kawakami H. Emerging Targeted Therapies for HER2 Positive Gastric Cancer That Can Overcome Trastuzumab Resistance[J]. Cancers, 2020, 12(2): 400. 11. Janjigian Y Y, Maron S B, Chatila W K, et al. First-line pembrolizu...
[24] Updated analysis of DESTINY-Gastric02: A phase II single-arm trial of trastuzumab deruxtecan (T-DXd) in western patients (Pts) with HER2-positive (HER2+) unresectable/metastatic gastric/gastroesophageal junction (GEJ) cancer who progressed on or after trastuzumab-containing regimen. 2022 ESM...
Advanced stomach cancer is associated with a poor prognosis, the average time patients survive after diagnosis is approximately 10 months with currently available therapies. Approximately 22% of stomach tumours overexpress HER2. "Herceptin was a breakthrough treatment for patients...
【关键词】胃癌;人表皮生长因子受体;曲妥珠单抗抵抗;多靶点酪氨酸激酶抑制剂;二线治疗;靶向治疗中图分类号:R735.2 文献标识码:A 文章编号:1671-8194(2013)21-0092-04Present and Future T argeted T herapy of HER2- positive Advanced Stomach CancerYU Wen, LIU Bao-qing, MEN Si-ye, XUE Wu-song*, ...
9. Shitara K, Bang YJ, Iwasa S, et al. Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer. N Engl J Med. 2020 Jun 18;382(25):2419-2430. 10. Lin Shen,1 Ping Chen, Jin Lu, et al. Trastuzumab deruxtecan in Chinese patients with previously treated HER2-positive...
6. American Cancer Society. Stomach Cancer: Early Detection, Diagnosis, and Staging. Available at: https://www.cancer.org/cancer/stomach-cancer/detection-diagnosis-staging/survival-rates.html. 7. Curea F.G, et al. Current Targeted Therapies in HER2-Positive Gastric Adenocarcinoma. Cancer Biotherap...
[4]Shen L, Chen P, Lu J, et al. Trastuzumab deruxtecan (T-DXd) in Chinese patients (pts) with previously treated HER2-positive locally advanced/metastatic gastric cancer (GC) or gastroesophageal junction adenocarcinoma (GEJA): Primary efficacy and safety from the phase II single-arm DESTINY...