BRCA1/2 mutations occurred in 6.6% of patients with human epidermal growth factor receptor 2 (HER2/neu)‐positive breast cancer. However, BRCA mutation status did not affect survival outcomes in patients who had HER2/neu‐positive breast cancer....
In univariate log-rank testing, HER2-positive patients were significantly more likely to relapse on tamoxifen, giving 5-year breast cancer-specific survival rates of 68% compared with 96% for the HER2-negative group (P<0.001, Figure 1). This significance was retained in Cox regression analysis ...
7、Diéras, Véronique et al.“Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label,...
[2]Hamilton EP, Hurvitz SA, Im SA, et al. Trastuzumab deruxtecan (T-DXd) vs trastuzumab emtansine (T-DM1) in patients (pts) with HER2+ metastatic breast cancer (mBC): Updated survival results of DESTINY-Breast03. 2024 ASCO. 1025. [3]Hurvitz SA, Hegg R, Chung WP, et al. Trastuzum...
[3]Hurvitz S, Hegg R, Chung WP, et al. Trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer: Updated survival results of the randomized, phase 3 study DESTINY-Breast03. 2022 SABCS. GS2-02. ...
Piccart M J ,et al.Ten-year survival of neoadjuvant dual HER2 blockade in patients with HER2-positive breast cancer[J].European journal of cancer: official journal for European Organization for Research and Treatment of ...
de Azambuja E, Holmes AP, Piccart-Gebhart M, et al. Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): survival outcomes of a randomised, open-label, multicentre, phase 3 trial and their association with pathological complete response. Lancet Oncol. 2014;15(10):1137...
The long-sought discovery of HER2 as an actionable and highly sensitive therapeutic target was a major breakthrough for the treatment of highly aggressive HER2-positive breast cancer, leading to approval of the first HER2-targeted drug — the monoclonal
Surgery was associated with higher survival rates for patients with HER2-positive (HER2+) stage 4 breast cancer compared with those who did not undergo surgery, according to results presented at the AACR Annual Meeting 2019, March 29-April 3. ...
[5] PS2-01: Dalpiciclib versus placebo in combination with letrozole or anastrozole as first-line treatment for women with HR+/HER2- advanced breast cancer: prespecified final analysis of progression-free survival of the phase 3 DAWNA-2 trial. SABCS 2024. ...