BRCA1/2 mutations occurred in 6.6% of patients with human epidermal growth factor receptor 2 (HER2/neu)‐positive breast cancer. However, BRCA mutation status did not affect survival outcomes in patients who had HER2/neu‐positive breast cancer....
trastuzumab did not alter invasive disease-free survival (iDFS), 5-year interval without distant recurrence, or overall survival (OS) in patients with HER2-low breast cancer. Recent years have seen the emergence of clinical trials for targ...
HER2 (ERBB2 or HER2/neu) is a tyrosine-kinase increasing cell proliferation. Overexpression/amplification of HER2 is correlated with worse prognosis in solid malignancies. Consequently, HER2 targeting is established in breast and upper gastrointestinal tract cancer. There are conflicting data concerning ...
HER2-expressing breast cancer cells use the PD-1/PD-L1 checkpoint axis to evade cytotoxicity by immune cells59,60. It should be noted that PD-L1, a ligand for PD-1, seems to be constitutively expressed in a subset of HER2+breast cancer patients61. Higher PD-L1 expression on HER2+breast...
HER2/neu Blocks Tumor Necrosis Factor-induced Apoptosis via the Akt/NF-kappa B Pathway Overexpression of HER-2/neu correlates with poor survival of breast and ovarian cancer patients and induces resistance to tumor necrosis factor (TNF), whic... BP Zhou - 《Journal of Biological Chemistry》 被...
2.Seshadri R, Firgaira FA, Horsfall DJ, McCaul K, Setlur V, Kitchen P. Clinical significance of HER-2/neu oncogene amplification in primary breast cancer. The south Australian breast cancer study group. J Clin Oncol. 1993;11(10):1936–42. ...
HER2/neu in the management of invasive breast cancer BACKGROUND: The aim of this study was to evaluate pancreatogastrostomy (PG) permeability after duodenopancreatectomy (PD) and to determine a correlation wi... F Meric,MC Hung,GN Hortobagyi,... - 《J Am Coll Surg》 被引量: 127发表: ...
1.Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987;235(4785):177–82. 2.Seshadri R, Firgaira FA, Horsfall DJ, McCaul K, Setlur V, Kitchen P. Clinical...
Breast Cancer Res Treat 100: 52 Google Scholar Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235: 177–182 Article CAS Google Scholar Smith I, Procter...
Abstract P5-18-23: The prognosis of T1a, T1b N0 M0, HER2+ patients in Korea.Backgrounds: Increased expression of HER-2 or amplification of the HER-2/neu gene has been associated with a worse prognosis than with other breast ... JW Lee,HG Moon,W Han,... - 《Cancer Research》 被引...