The path followed by a case of HER2-negative HR-positive breast cancer from the moment of diagnosis to the present time: clinical caseIovanovici, LauraOncolog-Hematolog
The RNA4 classifier assigns low risk (0 votes) if ESR1-positive and ERBB2-low status, and AURKA expression value below the PGR-dependent cut point; and high risk (2 risk votes) if ESR1-negative, ERBB2-positive, or AURKA expression value above the PGR-dependent cut point. However, samples...
2. Is there room for targeting HER2-negative tumors with low HER2 expression (meaning cases with IHC score 1+ or 2+ not amplified by FISH)? Starting from the first question, the level of HER2 expression evaluated either by IHC or mRNA has been shown to be prognostic for metastatic BC pat...
We also performed 2 subgroup analyses that evaluated cost-effectiveness of treatment strategies in patients stratified by ER status of their cancer (ie, ER-positive or ER-negative cancers). In these subgroup analyses, we used ER-specific rates of pCR for each neoadjuvant treatment regimen,5,41and...
In the past decades, transcriptomic studies have revolutionized cancer treatment and diagnosis. However, tumor sequencing strategies typically result in loss of spatial information, critical to understand cell interactions and their functional relevance.
To test the hypothesis that tissues predicted to be ER-positive or negative may have similar visual characteristics, we embedded fingerprints from whole-slides into a low dimensional space using a fast implementation of the tSNE algorithm. tSNE is an unsupervised non-linear technique which compresses...
Patients were stratified at randomization based on 3 factors, including tumor progression to metastatic phase in 2 or fewer years or more than 2 years after primary diagnosis, centrally determined estrogen receptor and progesterone receptor status (≥1 positive or both negative), and type of taxane...
For example, diagnosis of cancer can include one or more of a physical exam, laboratory tests, imaging analysis, and biopsy. After cancer is diagnosed, a variety of tests may be carried out to look for specific features characteristic of different types and or the extent of cancer in the ...
Overall, the score performed well in predicting cardiotoxicity in very-high-risk patients and had excellent negative predictive power. Amongst the four groups, the two groups that fell within the estimations of the HFA-ICOS were those in the medium-risk category and very-high-risk category. ...
HER3 is often correlated with poorly differentiated biliary tumors [81] and appears to be a poor prognostic factor in EHCCs [76], whereas the prognostic meaning of HER2 has not been completely clarified [79, 87]. Interestingly, the combination of pertuzumab and trastuzumab has been reported to...