HER2 Immunohistochemistry (IHC) on xenograft tumors IHC was performed on 4-μm thick formalin-fixed, paraffin-embedded xenograft or patient-derived xenograft sample sections mounted on glass slides. For HER2, staining was performed on the Ventana Discovery XT Autostainer platform (Ventana Medical System...
95% CI 40.8–84.6) patients presented a decrease of HER2 tumor expression after resistance to the drug, namely three IHC 3+ (two to IHC 2+ and one to IHC 1+), six IHC 2+ (three to IHC 1+ and three
(all cell lines tested were HER2 IHC 3 + ) or expression of drug efflux pumps such as Pgp (cells were negative for Pgp expression). The differential response to DHES0815A may represent potential expansion of the treated patient population. Based on the difference in payload MOA, we ...
Modern Pathology (2011) 24, 1111–1119 HER2 gene amplification in micropapillary urothelial carcinoma CB Ching et al Table 2 HER2 protein expression by immunohistochemistry and corresponding HER2 gene amplification and aneusomy 17 IHC score Total number of patients (%, n ¼ 19) No. patients ...
(Day 20) tumour biopsies, surgical resection and if occurred, metastatic tumour samples.bTileplot outlines for each HER2+ breast cancer case in the TCHL WXS cohort (left-right) the type of tumour sample collected and clinicopathological characteristics (top-bottom). ER estrogen receptor, IHC ...