Xu B, Li W, Zhang Q, et al. Pertuzumab, trastuzumab, and docetaxel for Chinese patients with previously untreated HER2-positive locally recurrent or metastatic breast cancer (PUFFIN): a phase III, randomized, double-blind, placebo-controlled study. Breast Cancer Res Treat. 2020 Aug;182(3):68...
Malignant neoplasm of breasttrastuzumab蛋白质酪氨酸激酶HER-2 is a tyrosine kinase receptor which is overexpressed in 20-25% of breast cancer patients and is associated with poor prognosis. Trastuzumab, a humanized monoclonal antibody directed against the HER-2 receptor, used alone or in combination ...
BRCA1/2基因突变,导致其抑制肿瘤发生的功能受到影响。研究表明,5%~10%的乳腺癌患者具有明确的遗传基因突变,称之为遗传性乳腺癌(hereditary breast cancer,HBC),其中BRCA1/2基因突变占15%。 携带BRCA1/2基因突变的女性不仅乳腺癌发病风险增加,其他如卵巢癌、输卵管癌、胰腺癌、胃肠癌及黑素瘤等发病风险也增加,男性...
Jordan, Nicole Vincent et al. “HER2 expression identifies dynamic functional states within circulating breast cancer cells.” Nature vol. 537,7618 (2016): 102-106. doi:10.1038/nature19328 Rugo, Hope S et al. “Efficacy of Margetuximab vs Trastuzumab in Patients With Pretreated ERBB2-Positive ...
6. Curigliano G, Mueller V, Borges V, et al. Tucatinib versus placebo added to trastuzumab and capecitabine for patients with pretreated HER2+ metastatic breast cancer with and without brain metastases (HER2CLIMB): fi...
[2] Pernas S, Tolaney SM. Clinical trial data and emerging strategies: HER2-positive breast cancer. Breast Cancer Res Treat. 2022 Apr 9. [3] 生物类似药研发与评价技术指导原则(试行) [4] NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Breast Cancer,NCCN Guidelines for Patien...
1.Antibody-Drug Conjugates Targeting theHuman Epidermal Growth Factor Receptor Family in Cancers. Front Mol Biosci. 2022;9: 847835. 2. Implementing antibody-drugconjugates (ADCs) in HER2-positive breast cancer: state of the art and futuredirections. Breast Cancer Res. 2021; 23: 84....
Sarah Talks About Her Breast Cancer Battle (VIDEO) 3 of 3 : Current video Sarah, a breast cancer survivor, found a lump on her breast three months before her wedding and was diagnosed soon after. Sarah: I was 28 when I was diagnosed. I actually found a lump myself and then was get...
号外号外,每周三的清晨,我们将推出全新的栏目,医海蠡测。如果我们把breast cancer 作为关键词,在pubmed上搜索近5年的文献,结果是353897篇,2017年就有21231篇,面对海量的文献,通读已不可能。在浩如烟海的文献中,通过兴趣,通过研究方...
"Every two minutes, a woman is diagnosed with breast cancer in the United States. On June 21st, I became one of them," she wrote in a social media post shared Wednesday morning. "As we approach #BreastCancerAwarenessMonth, I wanted to share my personal story with you all and encourage ...