Hepcidin itself is regulated by the supply of iron, the need for erythropoiesis, and the state of inflammation. Alterations in hepcidin levels are associated with restricted erythropoiesis, anemia, and iron overload. Discovery of hepcidin and elucidation of its mechanism of action and consequences of...
Hepcidin itself is regulated by the supply of iron, the need for erythropoiesis, and the state of inflammation. Alterations in hepcidin levels are associated with restricted erythropoiesis, anemia, and iron overload. Discovery of hepcidin and elucidation of its mechanism of action and consequences of...
Our objective was to evaluate the use of hepcidin to discriminate tumor-related IDA and ACD and to investigate the mechanism of action of hepcidin in these anemias.Shu, TingtingJing, ChangwenLv, ZhigangXie, YuchunXu, JiarenWu, Jianzhong
Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin 2018, Blood Show abstract Ironing out Ferroportin 2015, Cell Metabolism Show abstract Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis 201...
et al. Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin. Blood 131, 899–910 (2018). PubMed PubMed Central Google Scholar De Domenico, I. et al. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol....
Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action by hepcidin. Blood 131, 899-910 (2018).Aschemeyer S, Qiao B, Stefanova D...
The mechanism of action for these drugs is not mediated via hepcidin binding. Lexapteptid pegol27 (RNA aptamer) and 12B9m28 (monoclonal antibody) are reported to bind hepcidin and inhibit its activity. The basic disadvantage exhibited by these reagents is their processing and delivery. In this...
These findings suggest a mechanism of cytotoxic action of TH1-5 and indicate that TH1-5 may be a promising chemotherapeutic agent against human fibrosarcoma cells and human cervical epithelioid carcinoma cells. 展开 DOI: 10.6834/CSMU.2010.00084 年份: 2010 ...
Concerning the mechanism of hepcidin regulation, a single nucleotide deletion of hepcidin mRNA, an elongated abnormal polypeptide, a new stop codon, and a decreases of transcriptional activity have been postulated (Island et al., 2009; Papanikolaou et al., 2005; Roetto et al., 2003). However,...
Recently, it has been uncovered that another pro-inflammatory cytokine IL-1β stimulates hepcidin expression through the distinct mechanism underlying IL-6-mediated hepcidin transcription. In addition to IL-6 induction, IL-1β stimulates expression of CCAAT-enhancer-binding protein (C/EBP)δ, a ...