Hepcidin level was correlated with SLEDAI score (Pearson's correlation) and compared between patients with and without coronary calcification (Mann Whitney rank sum test).Results290 SLE patients were recruited but interim data on 189 patients were analyzed. There were 178 (94%) women and 11 men....
By using multiple linear regression analysis in the BDL animal model, we could create a mathematic equation to predict the hepatic expression of hepcidin mRNA with the level of IL-6 mRNA (Log10Hepcidin ¼ 0.617 Â log10IL6–0.946 Â cholestasis (0,1)– 0.339; R2 ¼ 0.469, Po0.001...
At the mRNA level, splenic ferroportin expression was not altered following hepcidin treatment at either time point (data not shown). Download: Download high-res image (2MB) Download: Download full-size image FIGURE 2. Localization of iron transporters in mouse spleen (A,B) and duodenum (C,D...
While FPN level was altered, non-significant differences in total cellular iron content and transverse relaxation rates, before and after hepcidin treatment, led us to examine whether the correlation between MR signal and cellular iron content had been influenced by hepcidin. Having presented the varia...
In the liver, donor mRNA was approximately 7% to 8% of the level observed in the relevant BMT control group (Figure 3A). Because Kupffer cells represent approximately 20% of the liver, these results suggest approximately 35% to 40% repopulation of liver macrophages from the donor marrow, ...
[32], the meticulous matching of the controls for age and gender, recently established as major determinants of hepcidin-25 at population level [20, 34], as well as the systematic exclusion of even subclinical iron deficiency in controls, which both contributed to a more realistic comparison of...
The current study established that in turpentine-induced ane- mic mice, the elevated hepcidin level restricts iron efflux, causing hypoferrmia. We used this model of AI to test the hypothesis that the inhibition of hepcidin would stabilize FPN transporter that would in turn promote iron mcoomb...
Hep3B cells also endogenously express a low level of hepcidin that can be markedly induced by BMP6 (supplemental Figure 12A). Expression of fHjv, fNeo1, or fHjv/fNeo1 did not significantly increase hepcidin mRNA (supplemental Figure 12B-G). However, expression of HJV in HepG2 cells indeed...
Small heterodimer partner (SHP) is a transcriptional corepressor regulating diverse metabolic processes. Here, we show that SHP acts as an intrinsic negative regulator of iron homeostasis. SHP-deficient mice maintained on a high-iron diet showed increase
2C). The protein level of mask-MT2 was much higher than that of high MT2 group (Fig. 2B), suggesting that MT2-mask was much more stable than full-length MT2 in the liver. The decrease of hepcidin expression in the AAV8-MT2 group was associated with a parallel decrease in Id1 ...