Hepcidin level was correlated with SLEDAI score (Pearson's correlation) and compared between patients with and without coronary calcification (Mann Whitney rank sum test).Results290 SLE patients were recruited but interim data on 189 patients were analyzed. There were 178 (94%) women and 11 men....
The significant increase of cell surface fNeo1-ECD/TMD by fAlk3 was likely derived from the direct γ-secretase proteolysis of fNeo1, because its level was reduced by incubation with the γ-secretase inhibitor, LY450139 (Fig. 4C; top panel; lane 9/10). Consistently, the decrease of cell...
血患者的Hepcidin、LPS和IL一6三者均与血红蛋白无相关关系。结论 癌性贫血患者高表达Hepcidin、LPS和IL-6, Hepcidin与LPS和II一6均呈正相关关系;它们在癌性贫血的发生发展过程中起重要的作用。 关键词:Hepcidin;脂多糖;白介素一6;癌症;贫血 · 中图分类号:R730.4 ...
4 mo was similar compared to ferritin (sensitivity and specificity of 82.4 and 73.9% at a cutoff value of hepcidin < 26 ng/ml (area under the curve 0.813) and a sensitivity and specificity of 83.8 and 65.2% at a cutoff level of ferritin < 88 μg/l (area under the curve 0.852))...
While FPN level was altered, non-significant differences in total cellular iron content and transverse relaxation rates, before and after hepcidin treatment, led us to examine whether the correlation between MR signal and cellular iron content had been influenced by hepcidin. Having presented the varia...
In the 10-11d treatment group, despite injections starting prior to placental maturation, there was no difference in placental weight or placental nonheme iron concentration (Figure 5A-B), indicating that the level of iron restriction was insufficient to affect placental development. Download: ...
[32], the meticulous matching of the controls for age and gender, recently established as major determinants of hepcidin-25 at population level [20, 34], as well as the systematic exclusion of even subclinical iron deficiency in controls, which both contributed to a more realistic comparison of...
At the mRNA level, splenic ferroportin expression was not altered following hepcidin treatment at either time point (data not shown). Download: Download high-res image (2MB) Download: Download full-size image FIGURE 2. Localization of iron transporters in mouse spleen (A,B) and duodenum (C,D...
The current study established that in turpentine-induced ane- mic mice, the elevated hepcidin level restricts iron efflux, causing hypoferrmia. We used this model of AI to test the hypothesis that the inhibition of hepcidin would stabilize FPN transporter that would in turn promote iron mcoomb...
Quantification of iron level was performed as previously described by Torrance and Bothwell (1968) on fragments or total organs using IL test™ (Instrumentation laboratory). For histology, tissues were fixed in 4% formaldehyde, embedded in paraffin, mounted onto slides and stained with Prussian blu...