Hepatitis B Virus (HBV) is a DNA virus that utilizes a complex life cycle to replicate via an RNA intermediate transcript with the help of reverse transcriptase enzyme. Many steps in the life cycle of HBV have not been clearly understood mainly because of the lack of availability of culture ...
Chronic hepatitis B virus (HBV) infection is a major cause of liver disease and cancer worldwide for which there are no curative therapies. The major challenge in curing infection is eradicating or silencing the covalent closed circular DNA (cccDNA) form of the viral genome. The circadian factor...
Hepatitis B Virus Replication Cycle The virus replication cycle consists of several phases (Fig. 3). The initial phase includes the adhesion of mature virions to the cell membrane. Recently, the HBV virion entry receptor has been identified as the sodium/taurocholate cotransporting polypeptide (NTCP...
HBV seems to undergo very little long-term mutational variation despite multiple host–virus factors driving short-term viral variations. Viral diversity is generated by features of the unique replication cycle of HBV as well as by cellular host factors. A possible bottleneck in the establishment of...
(t)ide analogs offers the only means of interrupting this process. This article reviews the current level of knowledge relating to this important human pathogen and deals in turn with the taxonomy of the virus, its structure andgenome organization,life cycleand replication strategy, as well as ...
Resolved hepatitis B involves interaction between the virus and the immune system. A variety of mechanisms may be involved. Low-level HBV virus replication is the main cause of resolved HBV infection. Other causes include HBV gene mutation, HBV integration into the host chromosome, HBV infection ...
Hepatitis B virus: virology, molecular biology, life cycle and intrahepatic spread. Hepatol Int. 2017;11(6):500–8. Article CAS PubMed Google Scholar Bartenschlager R, Cosset FL, Lohmann V. Hepatitis C virus replication cycle. J Hepatol. 2010;53(3):583–5. Article PubMed Google Scholar...
Hepatitis B virus biology and life cycle 2020, Antiviral Research Citation Excerpt : Although it remains unknown how and where cccDNA is maintained in the nucleus, cccDNA resides episomally but is inherently stable, which thus functions as a template for viral replication over the long term. A ...
The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitis B or C virus. PLoS One 6, e24142. Google Scholar Wang et al., 1998 W.X. Wang, M. Li, X. Wu, Y. Wang, Z.P. Li HNF1 is critical for the liver-...
<div p-id="p-0001">The disclosure relates to a method of inhibiting synthesis of viral DNA in a mammal infected with a hepatitis B virus. This method includes administering at least one <i>Phyllanthus