Pawlotsky JM. Hepatitis C virus: from discovery to eradication in 40 years? Clin Microbiol Infect. 2011;17:105-106.Pawlotsky JM: Hepatitis C, virus: from discovery to eradication in 40 years? Clin Microbiol Infect 2011, 17:105-106....
As an enteric RNA virus, HEV can cause both disease outbreaks and sporadic cases. This virus belongs to theHepeviridaefamily and is characterized as a single-stranded, positive-sense RNA virus. Contamination of the water supply is the main cause of virus outbreaks, although there are evidence s...
discoveryeliminationHCVNobel PrizeThe Nobel Prize for Physiology or Medicine, in the year 2020, has been awarded to three scientists, Harvey Alter, Michael Houghton, and Charles Rice, for jointly discovering the hepatitis C virus (HCV). This remarkable achievement is a huge breakthrough in the ...
In fact, these drugs may pave the way to complete eradication of the disease. However, their actual price is exceedingly high and a strategy is necessary to guarantee wide and sustainable access to new therapies. 展开 关键词: Hepatitis C virus HCV Antiviral therapy ...
Three scientists who played central roles in the discoveryof the hepatitis C virus(丙型肝炎病毒) have been awarded theNobel Prize in Physiology or Medicine 2020. This prize will beshared by Michael Houghton, from the United Kingdom, andUnited States scientists Harvey J. Alter and Charles M. ...
Discovery of new Hepatitis C virus mechanism by Osaka University SPP inhibition reduces production of infectious HCV particles and pathogenesis, Credit: Aizawa and Okamato et al. Nat Commun (2016) Researchers at Osaka University, Japan uncovered the mechanisms that suppress the propagation of the ...
The scientific basis of combination therapy for chronic hepatitis B functional cure Article 11 January 2023 Global burden of hepatitis B virus: current status, missed opportunities and a call for action Article 06 April 2023 Breakthroughs in hepatitis C research: from discovery to cure Article...
Due to the low fidelity of the RNA-dependent RNA polymerase, Hepatitis C virus (HCV) mutates quite frequently. There are seven genetically divergent genotypes (GTs) distributed in the world, each of which contains several closely related subtypes. The peer-reviewed literatures reporting the prevalen...
The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection The discovery of asunaprevir (BMS-650032, 24) is described. This tripeptidic acylsulfonamide inhibitor of the NS3/4A enzyme is currently in phase III clini......
Researchers at Osaka University, Japan uncovered the mechanisms that suppress the propagation of the hepatitis C virus (HCV) with the potential of improving pathological liver conditions. Using model mice, they confirmed that when a certain enzyme is inhibited, HCV particle production is reduced leadin...