Hepatitis C virus Hepatitis C virus(HCV), discovered in 1989, was the long sought-after and highly elusive causative agent of post-transfusion non-A, non-B hepatitis. This hugely important discovery allowed rapid development of serological screening assays forHCVinfection and their adoption for bloo...
Reactive (positive). This means that you have been infected with hep C at some point, but you may not be currently infected. Your immune system may have fought off the virus on its own without treatment. If you're positive or think you've been exposed to the hep C virus within in pa...
Antibody reactive to a hepatitis C virus (HCV)-derived peptide capable of including HLA-A2 restricted cytotoxic T lymphocytes is detect- able in the majority of HCV-infected individuals without HLA-A2 restriction. Microbiol Immunol 2004;48:507-517....
Hepatitis C virus (HCV) has been reported to elicit B and T cell immunity in infected patients. Despite the presence of antiviral immunity, many patients develop chronic infections leading to cirrhosis, hepatocellular carcinoma, and liver failure that can require transplantation. We have previously de...
Hepatitis C Virus Viral Structure The discoveries of hepatitis A virus (HAV) and HBV between the years of 1967 and 1973116 were a medical breakthrough; however, it left many unanswered questions. For the next 16 years, patients with non-A non-B hepatitis became increasingly recognized as havin...
& Howard, C. A peptide mimotope of hepatitis C virus E2 protein is immunogenic in mice and block human anti-HCV sera. J Med Virol 82, 1655–1665 (2010). 13. Roccasecca, R. et al. Mimotopes of the hyper variable region 1 of the hepatitis C virus induce cross-reactive antibodies ...
Hepatitis C virus (HCV) infection results in the activation of numerous stress responses including oxidative stress, with the potential to induce an apoptotic state. Previously we have shown that HCV attenuates the stress-induced, p38MAPK-mediated up-regulation of the K+ channel Kv2.1, to ...
We propose that T cells harboring cross-reactive TCRs could serve as a therapeutic agent in these instances. With the use of hepatitis C virus, known for its genomic instability as a model for mutated antigen recognition, we demonstrate cross-reactivity against immunogenic and mutagenic ...
Chronic Hepatitis C virus (HCV) infection has been linked with B cell lymphoproliferative disorders and several autoimmune-related diseases. The mechanisms of how chronic viral infection affects B cell development and predisposes the patients to autoimmune manifestations are poorly understood. In this stud...
Aspects of the present invention relate to the discovery of a novel hepatitis C virus (HCV) isolate. Embodiments include HCV peptides, nucleic acids encoding said HCV peptides, anti