HBcAg is not detected in serum, but is an intracellular virion associated nucleocapsid antigen that is the product of the C gene alone. HBeAg therefore has substantial amino acid homology to HBcAg, and the proteins are cross-reactive at the T cell level. Studies using recombinant HBcAg and ...
If your HBsAb result is positive or "reactive"—meaning the surface antibodies are present—it usually means that you have recovered from a recent or previoushepatitis B infectionand that you are immune to the virus. If both the HBsAb and HBcAb are positive, you are said to be immune due ...
The anti–hepatitis B core antibody (anti-HBc) assay is used to detect antibodies to the hepatitis B core antigen, an intracellular antigen expressed in infected hepatocytes that cannot be detected in serum. From: Clinics in Geriatric Medicine, 2014 ...
Although both local and global CR distributions were similar for immunogens, the antigen distributions were strikingly different, with the local distribution being considerably skewed (Fig. 4C). However, most HVR1 variants were predicted to be largely non-immunoreactive with each other (52.8% of ...
Routine use of the automated chemiluminescent microparticle immunoassay Abbott ARCHITECT® anti-HBc for diagnosis of hepatitis B is limited in case of borderline reactive sera with low signal close to the cut-off index. In order to determine the significance of anti-HBc detection when borderline r...
G. et al. A systematic approach for the identification of novel, serologically reactive recombinant Varicella- Zoster Virus (VZV) antigens. Virol J 7, 165 (2010). 56. Hall, J. A., Gehring, K. & Nikaido, H. Two modes of ligand binding in maltose-binding protein of Escherichia coli. ...
Attempts to titrate infectious HEV were undertaken by inoculation of the liver homogenate preparations on the cell lines PLC/PRF/5, A549 and HepG2 followed by viral antigen detection by immunofluorescence. The cell lines were chosen according to published protocols for propagation of HEV [4, 19–...
Exclusion criteria included the presence of hepatitis B surface antigen, hepatitis C virus or human immunodeficiency virus antibodies, pregnancy, breastfeeding, concomitant or previous history of hepatocellular carcinoma, evolutive neoplasia likely to threaten 1-year outcome, uncontrolled bacterial infection wi...
Hepatitis B surface antibody (HBsAb) is an antibody that develops in response to the hepatitis B surface antigen (HBsAg), which is the outer shell of the hepatitis B virus (HBV). Positive HBsAb indicates past or resolving infection, and it remains detectable for life. ...
antigens to CD8+T cells. The second step is when MHC class I expressed by a hepatocyte (or other infected host cell) presents antigens, and allows CD8+T cells to recognize which host cells need to be killed. In the case of HCV, the host cell that needs to be killed is infected ...