Most individuals avoid contracting hepatitis B by getting the hepatitis B vaccine; however, some instances still occur. Behaviors that heighten the risk of contracting hepatitis B include having unprotected sex, sharing needles or drug paraphernalia and accidental sticks in the healthcare field....
function of its gene product, a type-III interferon (IFN-λ3), remains to be elucidated. Human BDCA3+DCs have also been shown to be a potent producer of IFN-λ3 in HCV infection, suggesting the possibility that BDCA3+DCs could play a key role in developing therapeutic HCV vaccine. Here...
Current preventive strategies in resource-limited settings fail mainly due to prohibitive costs of hepatitis B immunoglobulin (HBIG) and a high proportion of homebirths, meaning both HBIG and hepatitis B birth dose vaccine are not given. A new strategy for PMTCT without the necessity of HBIG, ...
Although HBV is a DNA virus, it is highly variable under immunity or drug induced selection pressure, resulting in vaccine-related escape mutants and drug resistance. To overcome these challenging problems new antivirals and optimised vaccines have to be developed. Key Words: Hepatitis B virus; ...
(d) hepatitis E surveillance was implemented before the p239 vaccine phase-3 clinical trial; the subjects acquiring hepatitis E were verified by abnormal ALT and simultaneous IgM/IgG seroconversion; (e) subjects in the placebo group who received hepatitis B vaccine and presented significantly positive...
3Institute for Interdisciplinary Medicine, Asklepios Klinik St Georg, University of Hamburg, Hamburg, Germany Abstract: Chronic hepatitis B is a numerically important cause of cirrhosis and hepatocel lular carcinoma, despite an effective prophylactic vaccine and well-tolerated and effective oral antivir...
The current lead candidate is a T cell based vaccine which recently completed a Phase II study which proved ineffective in preventing chronic infection8. Nevertheless, it is likely that a successful HCV vaccine will need to induce both T and B cell immune responses, as existing data suggests ...
HBV causes acute and chronic hepatitis B; chronic HBV infection puts more than 250 million virus carriers at a greatly increased risk to develop terminal liver disease, i.e., liver fibrosis, cirrhosis and hepatocellular carcinoma (HCC) [1]. While an effective prophylact...
Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses. Nat. Commun. 9, 5031 (2018). Article ADS PubMed PubMed Central Google Scholar Dupinay, T. et al. Discovery of naturally occurring transmissible chronic hepatitis B virus infection among Macaca ...
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