With acute HBV infection, after an incubation period of 4–10 weeks, HBsAg becomes detectable in the blood, typically with measurable HBV DNA [21]. Shortly after HBsAg becomes positive, the first antibody to core antigen (IgM anti-HBc) appears [22]. Because hepatitis B core antigen (HBcAg)...
Hepatitis B virusVirus-host interactionsHepatitis B virus (HBV) X protein (HBx) plays diverse roles in both viral life cycle and HBV-related carcinogenesis. Its interaction with DNA damage-binding protein 1 (DDB1) was shown to be essential for engendering cellular conditions favorable for optimal...
Impact of a policy to permit the return of donors repeat-reactive to the Abbott PRISM antibody to hepatitis B core antigen assay. BACKGROUND: The expected donor loss from recent implementation of antibody to hepatitis B core antigen (anti-HBc) testing in Canada was uncertain but poten... SF...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. The incidence of HCC varies considerably with the geographic area because of differences in the major causative factors. Chronic hepatitis B and C, mostly in the cirrhotic stage, are responsible for the great...
Testing for antibody to HCV is normally carried out as a two stage procedure. AnELISAformat is used for initial testing of serum or plasma from patients or blood donors. Repeatedly reactive samples are then re-tested by a second ELISA in a different format or by a supplementary assay such ...
乙型肝炎病毒Hepatitis B virus (HBV) 发表于2024年5月17日由上海金畔生物科技有限公司 乙型肝炎病毒Hepatitis B virus (HBV) 中国有约9000万乙肝病毒慢性感染者,占全国人口约7%。多数感染者没有症状,而且不知道已被感染,但每10名慢性感染者中,就可能有3人出现如肝硬化和肝癌等危及生命的严重并发症。
Autoreactive CD4+ LKM-specific and anticlonotypic T-cell responses in LKM-1 antibody-positive autoimmune hepatitis 1996. Autoreactive CD4+ LKM-specific and anticlonotypic T-cell responses in LKM-1 antibody-positive autoimmune hepatitis. Hepatology 24: 1416-1421... HF Lohr - 《Hepatology》 被引...
Therapeutic vaccination against chronic hepatitis B must overcome high viral antigen load and local regulatory mechanisms that promote immune-tolerance in the liver and curtail hepatitis B virus (HBV)-specific CD8 T cell immunity. Here, we report that th
Strunz B, Hengst J, Deterding K, Manns MP, Cornberg M, Ljunggren HG, et al. Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity. Nat Commun. 2018;9(1):2275. PubMedPubMed CentralGoogle Scholar ...
A self-adjuvanting multiepitope immunogen that induces a broadly cross-reactive antibody to hepatitis C virus[J].Hepatology,2007.911-920.doi:10.1002/hep.21538.Torresi J, Stock OM, Fischer AE, Grollo L, Drummer H, Boo I, Zeng W, Earnest-Silveira L, Jackson DC. A self-ad- juvanting ...