Hepatic steatosis is frequently detected during cross sectional imaging. Ultrasound (US), Computed Tomography (CT), and Magnetic Resonance Imaging (MRI) provide noninvasive assessment of liver parenchyma and can detect fat infiltration in the liver. However, the non-invasive quantification of hepatic ...
All agents but hydroxychloroquine have been discontinued. Response from John J. Cush, MD Methotrexate and many other antirheumatic drugs are relatively contraindicated in patients with preexisting or active liver disease.[1]Hepatic steatosis (fatty liver) is a common consequence of liver injury and ha...
The annual prevalence of CHB alongside MASLD is increasing. Currently, there is no agreement on how MASLD affects the outcomes of antiviral treatment for CHB. Previous studies suggested that hepatic steatosis could aid in the clearance of the hepatitis B virus [7], while others indicated it had...
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To investigate the role of intestinal YAP1 in hepatic inflammation and hepatic steatosis, YAP1 was knocked out in the murine intestine. The results revealed that YAP1 was expressed at the base of the crypt where ISCs were located in the Yap1fl/fl mice, which is consistent with the findings...
To investigate the role of intestinal YAP1 in hepatic inflammation and hepatic steatosis, YAP1 was knocked out in the murine intestine. The results revealed that YAP1 was expressed at the base of the crypt where ISCs were located in the Yap1fl/fl mice, which is consistent with the findings...
Hepatic steatosis affects ∼33% of adults in the U.S. and is strongly associated with obesity, insulin resistance, and type 2 diabetes mellitus (Browning et al., 2004). Of those individuals with hepatic steatosis, it is estimated that ∼15%–20% will progress to nonalcoholic ...
Fur- thermore, it showed that what differentiates the liver transcriptomes with and without steatosis is the prefer- ence of the former for T cell activation, myeloid leukocyte differentiation and engagement of genes in- volved in cell cycle regulation. Results Variable response to HFD in outbred ...
Steatosis is a necessary step in the pathogenesis of NAFLD, but inflammation is required to bring about stea- tohepatitis, which leads to chronic damage to hepatocytes and progressive fibrosis. It has been demonstrated that elevated proinflammatory cytokines expression, as TNF-α , promoted hepatic...
Perturbation of endoplasmic reticulum (ER) function is one of the causes of abnormal lipid biosynthesis. However, ER stress is activate Sphk2, which ameliorates hepatic steatosis and insulin resistance in mice [61]. In animal models, both S1PR2-/- and Sphk2-/- mice rapidly develop fatty ...