Indeed, silencing of the catalytic subunit of PP2A and/or inhibition of its activity using okadaic acid prevents glucose-induced reduction of MAM integrity and function. The importance of PP2A in the control of MAM is supported by the presence of PP2A at MAM interface, where it regulates Akt ...
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yet for most of that time their role in the pathogenesis of neurovisceral attacks has been unclear. Research has focused on two hypotheses that are not mutually exclusive. The first is heme deficiency, which could directly affect neuronal function in that these cells, like hepatocytes,...
Using AAV8-mediated Cre-LoxP recombination in p53 floxed mice (p53 flox/flox), we aimed to examine the role of the liver-specific down-regulation of p53 on hepatic function. One month after the AAVs injection, we found reduced protein levels of p53 in the liver (Fig. 1a), an increased...
function ultimately leads to abnormal lipid storage in the liver. More precisely, the alteration of ER stress function caused by TAp63α lead to increased protein levels of FAS in the liver of different animal models and the augmentedde novoTG lipogenesis in hepatocytes, without consistent changes...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
HDL-C; Test code: 7600, Quest Diagnostics, LLC Marlborough, MA) or hepatic protein panel (total protein, albumin, globulin, and albumin/globulin ratio) (Test code: 90843, Quest Diagnostics, LLC Marlborough, MA), every 1–2 h such that every other sample was assayed for the same panel...