Advanced DN exhibits nodular glomerulosclerosis, mesangiolysis, and tubulointerstitial fibrosis [1]. Control of blood glucose and blood pressure or the renin-angiotensin system (RAS) inhibition can slow, but not prevent, disease progression. DN has become a worldwide health problem. If not treated ...
Journal of Clinical Medicine Review Update on New Aspects of the Renin-Angiotensin System in Hepatic Fibrosis and Portal Hypertension: Implications for Novel Therapeutic Options Indu G. Rajapaksha 1 , Lakmie S. Gunarathne 1 , Peter W. Angus 2 and Chandana B. Herath 1,3,* 1 Department of...
Advanced stages of fibrosis reportedly lead to the loss of hepatic vitamin A content which is mostly stored in cytosolic LDs of HSCs. This mobilization is presumably due to an induction of RE hydrolase(s) (activity and/or expression), while the rate-limiting enzymes responsible are currently ...
Liver-related morbidity and mortality due to NAFLD are mostly observed in patients with advanced fibrosis and cirrhosis. Therefore, the effective use of dietary factors to alleviate hepatic steatosis, the early NAFLD pathogenesis, and preventing its worsening can solve a serious public health problem....
The molecular basis, by which H19 regulates liver fibrosis, has yet to be completely determined. Despite not directly controlling P450s or FXR expression, the knockdown of H19 still partially rescues BCL2-induced liver injury [62]. This partial rescue of injury may be an important observation ...
Keywords: ethanol; carbon tetrachloride; inflammation; liver regeneration; matrix remodeling; wound healing; fibrosis 1. Introduction Ethanol consumption contributes to liver injury and subsequent alterations in hepatic structure and function. If prolonged, ethanol exposure can precipitate the progression of ...
Liver cirrhosis is caused by the severe scarring of the liver and an advanced state Int. J. Mol. Sci. 2021, 22, 239 6 of 21 of liver fibrosis. The liver architecture is distorted and increased portal blood flow results in portal hypertension. Hepatic cirrhosis is the irreversible end ...
* and Feng Zhou 1,* 1 Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, 17 Tsinghua East Road, Beijing 100083, China; liangzhao@...