It is concluded that heparin stimulates release of LA-PF4 from platelets both in vitro and in vivo. LA-PF4 has antiheparin action and is being investigated as a marker for thrombosis. Its release by heparin may, therefore, have an important implication....
Do not use this medicine if you have ever been diagnosed with “heparin-induced thrombocytopenia,” or low platelets caused by heparin or pentosan polysulfate.Heparin increases your risk of bleeding, which can be severe or life-threatening. You will need frequent tests to measure your blood-...
Heparin and platelets. 来自 NCBI 喜欢 0 阅读量: 42 作者: Theodore E. Warkentin,John G. Kelton 摘要: Heparin-induced thrombocytopenia is the most important immune drug-induced thrombocytopenia because of its relatively high frequency and association with arterial and venous thromboembolism. The ...
Owing to their smaller size, however, low-molecular-weight heparin does not interact with platelet factor 4 and platelets as efficiently as does unfractionated heparin. This translates to a two- to threefold lower risk of immune sensitization (antibody generation and occurrence of clinical heparin-...
Platelet levels may also be low due to decreased production in the bone marrow as is seen with : Alcohol abuse Leukemia Lymphoma Aplastic anemia and other types of anemia In the event of splenomegaly (enlarged spleen), platelets in the circulation may become trapped within the spleen. Therefore...
HIT is a serious antibody-mediated reaction resulting from irreversible aggregation of platelets. HIT occurs in patients treated with heparin and is due to the development of antibodies to a platelet Factor 4-heparin complex that induce in vivo platelet aggregation. HIT may progress to the developmen...
UFH also binds endothelial cells, platelet factor 4, and platelets, leading to rather unpredictable pharmacokinetic and pharmacodynamic properties. Variability in activated partial thromboplastin time (aPTT) reagents necessitates site-specific validation of the aPTT therapeutic range in order to properly ...
The pathogenesis is due to an antibody response to the complex heparin/platelet factor 4 in most cases, with secondary activation of platelets and ... Greinacher, Andreas - 《Seminars in Thrombosis & Hemostasis》 被引量: 220发表: 2006年 Heparin coating of the stent graft — effects on platel...
while the delayed reaction involves the production of heparin-dependent antiplatelet antibodies and the clearance of platelets from the blood. Heparin-associated thrombocytopenia may be associated with irreversible aggregation of platelets (white clot syndrome). Additional untoward effects of heparin treatment...
You should not use heparin if you have uncontrolled bleeding or a severe lack of platelets in your blood. Do not use this medicine if you have ever been diagnosed with “heparin-induced thrombocytopenia,” or low platelets caused by heparin or pentosan polysulfate....