Heparin-bonded central venous lines reduce thrombotic and infective complications in critically ill children. Intensive Care Med 2000;26:967--72.Pierce CM, Wade A, Mok Q. Heparin-bonded central venous lines reduce thrombotic and infective complications in critically ill children. Intensive Care Med....
Central venous access (CVA) is widely used. However, its thrombotic, stenotic and infectious complications can be life-threatening and involve high-cost th... X Ge,R Cavallazzi,C Li,... - 《Cochrane Database of Systematic Reviews》 被引量: 221发表: 2012年 Incidence of thrombotic complicati...
Therefore, the increased nuclear accumulation of YAP/TAZ as transcription coactivators promotes the expression of the central mediator of tissue fibrosis-CTGF by binding with the TEAD complex in the nucleus.119–121 The overexpression of CTGF, which contributes to fibrosis, can also occur through ...
PROSS engineering achieves the maximum accumulation of mutations. However, iterative saturated evolution of up to 39 sites would require a substantial physical effort, limiting the scope for creating stable biocatalysts through stepwise combinations alone. Hence, knowledge-guided approaches are essential to ...
Recent advancements in metabolic engineering and synthetic biology offer alternatives through bioengineered heparin production, albeit with challenges such as controlling molecular weight and sulfonation patterns. This review offers comprehensive insight into recent advancements, encompassing: (i) the metabolic ...
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Laboratory data, concomitant drugs administered, number of transfusions given, and numbers/types of lines used, such as arterial lines or central venous catheter information, were also collected. Statistical analyses The Shapiro-Wilkes test was used to evaluate the normality of the heparin infusion ...
Low-molecular-weight heparin (LMWH), derived from unfractionated heparin (UFH), has enhanced anticoagulant efficacy, long duration of action, and extended half-life. Patients receiving LMWH for preventive therapies would strongly benefit from its long-te
Long, sulfated oligosaccharides can be obtained by connecting two sequences such as ABD and TBD through a spacer. Several aspects need to be considered in defining the nature of the spacer: (1) the type of spacer (charged or neutral, linear, flexible or rigid); (2) the direction of ...
All preparations were sterilized before injection by passing them through a 0.22-μ or a 0.45-μ Millipore filter in the presence of a human albumin solution (GPO plasma substitute, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam). Table 1. Characteristics of ...