Heparin has a short half-life (8 to 12 hours) and therefore must be administered by continuous infusion or by intermittent subcutaneous injection. Intermittent subcutaneous injection may lead to fluctuation in the levels of anticoagulation attained. In correcting this deficiency, the programmable ...
especially activated factor X. It also binds to other plasma proteins, including fibrinogen, plasmin, albumin, and Upases. The volume of distribution of heparin is then, under most circumstances, limited to the plasma volume. Heparin has a very short half-life...
a period of at least 5 hours after the last intravenous dose or 24 hours after the last subcutaneous dose should elapse before blood is drawn if a valid prothrombin time is to be obtained.
Low-molecular-weight heparin has a high bioavailability and a prolonged half-life in comparison with conventional unfractionated heparin. Limited data are available for low-molecular-weight heparin as compared with unfractionated heparin for the treatment of deep-vein thrombosis. In a multicenter, double...
Heparin N.M.Acquisto, inEncyclopedia of Toxicology (Third Edition), 2014 Abstract Heparinpotentiates the action of antithrombin III to produce its anticoagulant effects. It is used as a parenteral or subcutaneous agent for the treatment or prevention of thromboembolic events. Low-molecular-weight hepa...
hour delay in onset of drug action after subcutaneous administration. Intramuscular injection of heparin is to be avoided because of unpredictable absorption rates, local bleeding, and irritation. Heparin is not bound to plasma proteins or secreted into breast milk, and it does not cross the ...
Necrosis of the skin has been reported at the site of subcutaneous injection of heparin [see Warnings and Precautions (5.7), Adverse Reactions (6)]. Other Medications Because of the risk of hemorrhage, advise patients to inform their physicians and dentists of all medications they are taking,...
Whereas heparin is only 30% absorbed following subcutaneous injection, 90% of LMWH is systemically absorbed. The binding affinity of heparin to various protein receptors, such as those on plasma proteins, endothelial cells, platelets, platelet factor 4 (PF4), and macrophages, is very high and is...
and half-life. Subcutaneous injection can lead to rapid absorption. Low molecular weight heparin having a significant and long-lasting antithrombotic effect. Its antithrombotic activity is stronger than the anticoagulant activity. Thus there is a relative small risk of simultaneously occurrence of ...
Life-threatening hemorrhage following subcutaneous heparin therapy. J Hudcova,D Talmor - 《Therapeutics & Clinical Risk Management》 被引量: 0发表: 2008年 Stroke after thrombolysis. Mortality and functional outcomes in the GUSTO-I trial. Global Use of Strategies to Open Occluded Coronary Arteries. ...