Heparin: new life for an old drug Nanomedicine, 12 (2017), pp. 1727-1744, 10.2217/nnm-2017-0127 View in ScopusGoogle Scholar Al-Hakim, 2021 A. Al-Hakim General considerations for diversifying heparin drug products by improving the current heparin manufacturing process and reintroducing bovine sou...
cardiopulmonary bypassmechanical assist deviceHeparin-induced thrombocytopenia (HIT) is a rare but life-threatening adverse effect of heparin therapy. Immediate cessation of heparin and alternative anticoagulation are basic therapeutic principles of HIT. This is especially difficult in HIT patients requiring ...
Although the thrombin inhibition is a desirable effect of heparin, nonspecific interactions with other proteins (e.g., platelet factor 4) result in life-threatening side effects (Fig. 10b) (95–97). Sign in to download full-size image Figure 10. Heparin catalysis of thrombin inhibition by ...
The use of RCA is associated with metabolic complications, including possible life-threatening systemic hypocalcemia and metabolic alkalosis. Citrate is metabolized mainly in the liver into three moles of bicarbonate. Exposure to excessive citrate results in metabolic alkalosis in cases with sufficient live...
Roughly 12 million patients are exposed to heparin annually (Sankar Eke 2014) and up to 1% of these patients will develop heparin-induced thrombocytopenia (HIT), a life-threatening complication where patients make antibodies that bind to the heparin/PF4 complex. These antibodies trigger the ...
although it is unclear from the literature if any homozygous deficient infant has ever survived to the point of birth, life threatening thrombotic complications with ATIII levels of less than 0.25 Units/ml in heterozygotes requiring ATIII plus heparin may occur in up to 1 or 2 infants per yea...
Heparin-induced thrombocytopenia (HIT) is a life- and limb-threatening immune-mediated emergency classically associated with heparin therapy. This review focuses on type II HIT, characterized by the development of antibodies against platelet-factor 4 (PF4) bound to heparin after exposure, causing life...
The aim was to distinguish clearly between early, transient, clinically non-consequential, type 1 HIT (sometimes also called "non-immune heparin- associated thrombocytopenia" [38]) with the potentially life- and limb-threatening "type 2", or "delayed-onset", HIT disorder mediated by platelet-...
What are the contraindications for low molecular weight heparin? Discover how ClinicalKey AI answers this and other questions from clinicians about medical topics.
1, 5 This limb- and life-threatening condition must be rapidly and reliably distinguished from other causes of thrombocytopenia6 to immediately stop all heparin sources and switch to alternative nonheparin anticoagulants (argatroban,7, 8 danaparoid,9 fondaparinux,10 or a direct oral anticoagulant11)....