Low doses of heparin are cleared mostly by a saturable, rapid, zero-order process. Slower first order elimination usually occurs with very high doses of heparin and is dependent on renal function. The plasma half-life is dose-dependent, and it ranges from 0.5 to 2 h. Specific Populations...
Adjust the dosage of heparin sodium according to the patient’s coagulation test results. When heparin is given by continuous intravenous infusion, determine the coagulation time approximately every 4 hours in the early stages of treatment. When the drug is administered intermittently by intrav...
The reaction rate is practically limited by heparin concentration, and heparin is cleared from circulation with a half-life of between 1 h and 4 h depending on heparin molecular weight. Heparin dosing is made on the basis of activity in solution (expressed in International Units) and in ...
incidence of HIT. Heparin is subject to fast zero-order metabolism in the liver, followed by slower first-order clearance from the kidneys. The LMWHs are renally cleared and follow first-order kinetics. This makes the clearance of LMWHs more predictable as well as resulting in a prolonged ...
Heparin half-life is also dose dependent with higher doses taking longer to be cleared from the bloodstream (Weitz and Weitz, 2010). 4.1 Heparin-mimetics To overcome these drawbacks, developing heparin-mimetic polymers that are easily obtainable in large scale with predictable bioactivity and ...
Heparin is subject to fast zero-order metabolism in the liver, followed by slower first-order clearance from the kidneys. The LMWHs are renally cleared and follow first-order kinetics. This makes the clearance of LMWHs more predictable as well as resulting in a prolonged half-life. Finally, ...
Heparin Lock Flush Solution may also be used after each withdrawal of blood for laboratory tests. When heparin (or sodium chloride) would interfere with or alter the results of blood tests, the heparin solution should be cleared from the device by aspirating and discarding it before withdrawing ...
Several infections are successfully combated by the immune system of a mammal such as a human being. However, in some instances, bacteria, fungi, or viruses are not always cleared, which may cause localised or generalised acute infections. This is a serious concern at perinatal-, burn, or in...
At therapeutic doses, heparin is clearedpredominantly through the rapid saturable, dose-dependent mechanism andits anticoagulant effects are nonlinear, with both the intensity andduration of effect rising disproportionately with increasing dose. Guide to anticoagulant therapy: Heparin: A statement for ...
The lysate is cleared by sonication, and cell debris is pelleted by centrifugation for 10 minutes at 12,000 X g. The fusion protein-containing pellet is resuspended in 50 mM Tris, pH 8, and 10 mM EDTA, layered over 50% glycerol, and centrifuged for 30 min. at 6000 X g. The pellet...