the effects on the breastfed infant, or the effects on milk production. Due to its large molecular weight, heparin is not likely to be excreted in human milk, and any heparin in milk would not be orally absorbed by a
Heparin is mainly cleared from the circulation by liver and reticuloendothelial cells mediated uptake into extravascular space. Heparin undergoes biphasic clearance, a) rapid saturable clearance (zero order process due to binding to proteins, endothelial cells and macrophage) and b) slower first order...
Low doses of heparin are cleared mostly by a saturable, rapid, zero-order process. Slower first order elimination usually occurs with very high doses of heparin and is dependent on renal function. The plasma half-life is dose-dependent, and it ranges from 0.5 to 2 h. Specific Populations...
At therapeutic doses, heparin is clearedpredominantly through the rapid saturable, dose-dependent mechanism andits anticoagulant effects are nonlinear, with both the intensity andduration of effect rising disproportionately with increasing dose. Guide to anticoagulant therapy: Heparin: A statement for ...
Heparin half-life is also dose dependent with higher doses taking longer to be cleared from the bloodstream (Weitz and Weitz, 2010). 4.1 Heparin-mimetics To overcome these drawbacks, developing heparin-mimetic polymers that are easily obtainable in large scale with predictable bioactivity and ...
anti- coagulant pro~le of unfractionated heparin is in_uenced by the chain length of the molecular, and its clearance of unfractional heparin is in_uenced by its molecular size, with the higher molecular weight ele- ments being cleared more rapidly than the low molecu- lar weight ones (3...
incidence of HIT. Heparin is subject to fast zero-order metabolism in the liver, followed by slower first-order clearance from the kidneys. The LMWHs are renally cleared and follow first-order kinetics. This makes the clearance of LMWHs more predictable as well as resulting in a prolonged ...
Heparin is subject to fast zero-order metabolism in the liver, followed by slower first-order clearance from the kidneys. The LMWHs are renally cleared and follow first-order kinetics. This makes the clearance of LMWHs more predictable as well as resulting in a prolonged half-life. Finally, ...
Preservative-Free Heparin Lock Flush Solution, USP may also be used after each withdrawal of blood for laboratory tests. When heparin would interfere with or alter the results of blood tests, the heparin solution should be cleared from the device by aspirating and discarding it before withdrawing ...
At explant, two representative 2 cm segments from each graft were rinsed in isotonic saline, cleared of endogenous heparin in buffered 0.6 M borate in 0.01 M NaCl (pH = 9), and rinsed again with deionized H2O. Samples then were assayed for luminal-surface heparin activity measured as ...