Heparin, anticoagulant drug that is used to prevent blood clots from forming during and after surgery and to treat various heart, lung, and circulatory disorders in which there is an increased risk of blood clot formation. Discovered in 1922 by American
HNBF show a prominent 70-kDa band in SDS-NuPAGE.ConclusionsEndothelial-derived soluble factor(s) has a molecular weight higher than other growth factors, does not have affinity to heparin, is a protein, at least in the active part of the molecule and increases iSMC number due to increased ...
Noun1.heparin- a polysaccharide produced in basophils (especially in the lung and liver) and that inhibits the activity of thrombin in coagulation of the blood; it (trade names Lipo-Hepin and Liquaemin) is used as an anticoagulant in the treatment of thrombosis and in heart surgery ...
1. Cold-precipitation of a mass of gelatinous protein material is produced by heparin in plasma obtained from rabbits between one and 6 hours after an injection of endotoxin derived from gram negative bacteria. The precipitate is redissolved on warming the plasma. It is demonstrable within 15-...
Much like CSF, human plasma is characterized by a large dynamic range of protein abundance, estimated at 12–13 orders of magnitude [31], in which albumin and other high-abundant proteins can prevent the detection of proteins of interest. However, the concentration of albumin in plasma (~ ...
PURPOSE: A heparin-binding protein(HBP) of Korean mistletoe and an extraction method thereof are provided, which protein has improved anti-cancer and immunomodulating activity, so that it can be useful as functional food or food additives, and as injection for prevention and treatment of cancer. ...
Heparin Sodium Injection is supplied in vials containing various strengths of heparin, including vials that contain a highly concentrated solution of 10,000 units in 1 mL. Fatal hemorrhages have occurred in pediatric patients due to medication errors in which 1 mL Heparin Sodium Injection vials ...
Heparin is a complex glycosaminoglycan that inhibits vascular smooth muscle cell (SMC) growth in vitro and in vivo. To define the mechanism by which heparin exerts its antiproliferative effects, we asked whether heparin interferes with the activity of intracellular protein kinase C (PKC). The ...
Heparin (heparin sodium injectable) is a heterogeneous group of straight-chain anionic mucopolysaccharides, called glycosaminoglycans that haveanticoagulantproperties used to help prevent clot formation (for example, venousthrombosis, pulmonary embolisms, coagulopathies and coronary artery clots). Heparin is ...
intramolecular interactions that collectively control protein stability46,47. Recombinant NST proteins exhibit high catalytic efficiency but poor stability, with a half-life of <0.5 days. It is crucial that, in mutagenesis of the enzyme, enhancing stability should not compromise functional activity. Give...