Plasma antithrombin (AT) measured as heparin cofactor activity decreased 0.16 +/- 0.13 U/ml (mean +/- SD) in 198 patients who received heparin infusion during 1 wk for deep venous thrombosis (DVT). The decrease was weakly, but significantly correlated to heparin dose (r = 0.15, p = ...
Accepted initial therapy for deep vein thrombosis (DVT) is intravenous heparin infusion, which requires hospitalization, inhibits patient ambulation, consumes nursing time, and generates laboratory cost. The effects of heparin are unpredictable, and maintaining optimal anti-coagulation requires careful labora...
Bleeding complications occurred in 30 (11%) out of 280 patients who received continuous heparin infusion for deep venous thrombosis (DVT). 22 (8%) had minor while 8 patients (3%) had major bleeding complications (1 intrathoracic [fatal], 2 gastrointestinal and 5 retroperitoneal). Heparin activi...
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For patients currently receiving intravenous heparin, stop intravenous infusion of heparin sodium immediately after administering the first dose of oral anticoagulant; or for intermittent intravenous administration of heparin sodium, start oral anticoagulant 0 to 2 hours before the time that the next dose...
The aPTT is NOT recommended for monitoring low molecular weight heparin (which we’ll discuss more later). When an IV bolus of heparin is given, followed by a continuous IV infusion, the aPTT is evaluated every 6 hours during the first day of heparin therapy & 6 hours after any dosage ...
To determine the adequacy of initial anticoagulation by intravenous heparin for patients who have deep venous thrombosis (DVT), and the factors that influence delayed anticoagulation, independent, duplicate chart review of 63 consecutive patients who had venography-proven DVT was conducted. Adequate hepari...
Unfractionated heparin has been classified as ahigh-alert drugby the Institute for Safe Medication Practices. How quickly does heparin work? Heparin rapidly reduces the ability of the blood to clot. Heparin works immediately following direct IV injection or infusion. Workswithin 20 to 60 minutes fo...
Subjects. A total of 330 patients, of 20 years or older, with suspected DVT, verified using venography. Interventions. Fixed-dose dalteparin (200 IU kg-1) given as a once-daily subcutaneous injection, or aPTT adjusted i.v. UFH infusion for 6 to 10 days. Main outcome measures. Change...
34-36,44 Low-molecular-weight heparin treatment has been shown45-52 to be effective and safe in patients with DVT and may also be so in patients with PE. We conducted a double-blind, randomized trial comparing low-molecular-weight heparin (tinzaparin sodium) with intravenous heparin treatment ...