is serious (FDA MedWatch definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * requires intervention to prevent permanent impairment or damage
heparin for the prevention and treatment of thrombosis (83,84). This is particularly true for clot-bound thrombin which is protected from inhibition by heparin activated AT, but is vulnerable to dermatan sulfate activated HCII (85). The fact that HCII binds to dermatan sulfate, which is found...
These studies showed, for the first time, that an LMWH, i.e., Tinzaparin, only needed to be administered to the patient once a day to achieve a significant prophylactic effect [18]. The use of LMWHs was not accepted at this time as a treatment for existing blood clots. In these ...
You may not be able to use heparin if you are unable to receive routine blood-clotting tests at the proper intervals during treatment.To make sure heparin is safe for you, tell your doctor if you have ever had:an infection of the lining of your heart (also called bacterial endocarditis);...
Ventricular assist devices (VADs) are used to bridge patients for heart transplantation. Systemic treatment with anticoagulants is required to mitigate against clot formation in the equipment. However, serious thromboembolic events still occur. Application of the CBAS Heparin Surface to VADs developed ...
Heparin and heparin-like compounds are often prescribed as a treatment for patients with acutethromboembolism. The posited purpose ofheparinizationis to prevent propagation ofthrombiand break-off of the tail of existing thrombi and so prevent furtherembolization. As far as is known, heparin does ...
Heparin prevents blood clots by blocking the action of 4 of the 12 clot-promoting proteins in blood (factors II, VII, IX, X) whose action is necessary for blood to clot. Brand names available for heparin include Hemochron,Hep-Lock, Hep-Lock U/P, Heparin in 5% Dextrose, Heparin LockFlush...
After treatment, the clots were weighed, and the absolute and percent difference in weight was calculated. Immersion in heparin, tirofiban, and tPA without ultrasound did not augment clot disruption relative to normal saline alone. Immersion in Optison (p=0.07) tended to result in less lysis ...
Nevertheless, the intended clinical indications for anticoagulant drugs, with Oral heparin will be a particularly appropriate anticoagu- lant for indications that require prophylaxis or treatment for extended periods, months or indefinitely [59]. Extended prophylaxis is indicated as an example in situa-...
This compound is naturally found in the body and acts by enhancing the activity of antithrombin III, thus inhibiting blood clot formation. Heparin is commonly used in medical settings for the prevention and treatment of various conditions associated with blood clotting, such as deep vein thrombosis ...