Among 964 fibrinolytic-treated patients with STEMI, 758 (79%) received adjunctive unfractionated heparin therapy. Of these, 368 patients (49%) received excess dosing of unfractionated heparin and 137 patients (18%) received major excess heparin dosing. Factors significantly associated with excess ...
In addition, obtaining a valid therapeutic activated partial thromboplastin time (aPTT) in cardiology patients is a major challenge, and dosing is complex. Due to substantial variation in reagents and instruments, target aPTT ranges for UFH in ACS clinical trials cannot be extrapolated to individual ...
Current dosing of low-molecular-weight heparins does not reflect licensed product labels: an international survey Br. J. Clin. Pharmacol., 69 (5) (2010), pp. 520-528 CrossrefView in ScopusGoogle Scholar [226] S. Mengiardi, D.A. Tsakiris, M.L. Lampert, K.E. Hersberger Drug use prob...
Low molecular weight heparins (LMWHs) are as efficient as unfractionated heparin (UFH) for prevention and treatment of thromboembolism. There is no evidenc... B Boneu,de Moerloose, Philippe - 《Seminars in Thrombosis & Hemostasis》 被引量: 130发表: 2001年 Dosing and monitoring of low-molecul...
Treatment of STEMI (in both those undergoing percutaneous coronary intervention and those not) Unstable angina Prevention of clotting in extracorporeal circuits LMWHs are not the sole medications used for these purposes; therefore, a thorough understanding of the variously available anticoagulants and their...
In addition, obtaining a valid therapeutic activated partial thromboplastin time (aPTT) in cardiology patients is a major challenge, and dosing is complex. Due to substantial variation in reagents and instruments, target aPTT ranges for UFH in ACS clinical trials cannot be e 展开 ...
(activated partial thromboplastin time [APTT]-adjusted) direct thrombin inhibitor (DTI) therapy (argatroban, bivalirudin), either because of APTT confounding (where aHIT-associated DIC and resulting APTT prolongation lead to systematic underdosing/interruption of DTI therapy) or because DTI inhibits ...
In addition, obtaining a valid therapeutic activated partial thromboplastin time (aPTT) in cardiology patients is a major challenge, and dosing is complex. Due to substantial variation in reagents and instruments, target aPTT ranges for UFH in ACS clinical trials cannot be eDr. Thomas L. Rihn...
Introduction: UFH infusions are widely utilized for a variety of indications, including treatment of acute venous thromboembolism (VTE), ST-segment elevation myocardial infarction (STEMI) and bridging to warfarin therapy. Contemporary dosing strategies are often based on actual body weight (ABW). ...
ST-segment elevation myocardial infarction, and primary percutaneous coronary intervention.English-language randomized controlled trials and meta-analyses were eligible for inclusion for data review of STEMI where PPCI was performed.Either bivalirudin or UFH is recommended in the setting of STEMI where PPCI...