The pathogenic bacterium Helicobacter pylori, which causes active, chronic type B gastritis and peptic ulcer disease, and increases the risk for development of gastric cancer, could tentatively interfere with growth factors and growth factor receptors of importance for the gastroduodenal mucosa, e.g. ...
Both receptor binding and growth factor-mediated mitogenicity are dependent on heparin. Heparin-binding growth factor activity can thus be regulated by proteoglycans and by the type of FGF receptor expressed on the target cell.doi:10.1016/S0021-9258(18)42001-7Ornitz DM...
Auto-fibrillogenesis of fibronectin, binding to collagen, growth factors and proteoglycans are all dependent on intramolecular strain [48,49]. Mechanical stress was also shown to collaborate with heparin binding to determine fibronectin structure [50]. More complex extracellular signaling is established ...
while the delayed reaction involves the production of heparin-dependent antiplatelet antibodies and the clearance of platelets from the blood. Heparin-associated thrombocytopenia may be associated with irreversible aggregation of platelets (white clot syndrome). Additional untoward effects of heparin treatment...
Laminin, as a key component of the basement membrane extracellular matrix (ECM), regulates tissue morphogenesis. Here, we show that multiple laminin isoforms promiscuously bind to growth factors (GFs) with high affinity, through their heparin-binding dom
effects of concomitant medications. In clinical practice, the optimal timing, mode of administration and choice of anticoagulant therapy is dependent on the thrombolytic agent used; therefore, it should be noted that urokinase is not commonly used in the management of acute STEMI in Western countries...
Article: Heparin-binding EGF-like growth factor is an autocrine growth factor for rat gastric epithelial cells
42. Alban S: Molecular weight-dependent influence of heparin on the form of tissue factor pathway inhibitor circulating in plasma. Semin Thromb Hemost 2001, 27:503-511. 43. Bendz B, Hansen JB, Andersen TO, Ostergaard P, Sandset PM: Par- tial depletion of tissue factor pathway inhibitor ...
The immediate type is transient and may not involve platelet destruction, while the delayed reaction involves the production of heparin-dependent antiplatelet antibodies and the clearance of platelets from the blood. Heparin-associated thrombocytopenia may be associated with irreversible aggregation of ...
Top-down and bottom-up approaches were used to estimate and validate the size of the global Indian peptide and anticoagulant drugs industry and to estimate the size of various other dependent submarkets. The overall market size was used in the top-down approach to estimate the sizes of other ...