Hepatitis C virus (HCV) is a leading cause of liver-related mortality and morbidity. Despite effective direct acting antivirals and a simplified treatment ... A Desai,L O'Neal,K Reinis,... - 《Implementation Science Communications》 被引量: 0发表: 2023年 Hep C drugs approved for kids FDA...
Future therapies for chronic hepatitis C that have greater tolerability, simplified dosing schedules, shorter treatment duration, and more favorable safety profiles are needed to improve adherence and enhance treatment effectiveness, according to an abstract published in Value in...
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By transforming the home into a treatment center and delivering collaborative care with lived experience to those in need, Aware empowers individuals and their loved ones to thrive and make sustainable recovery possible. The program helps clients learn new skills and daily habits to achieve and main...
Fig. 4.(A) Simplified ELSD calibration scheme: calibration curve using five saccharides, each at a different concentration, in a single standard mixture. (B) Curve fitting residual using a pooled data calibration model (o) and using a simplified calibration model (+). ...
Peptides have been used as imaging agents owing to their relatively faster clearance compared to antibodies and simplified bifunctional chelation chemistry allowing for use of various radiometals. Based on the discussed peptide scaffolds, several peptide-based CXCR4 imaging agents were investigated. The ...
*P < 0.05 in comparison to cells infected with AdGFP or AdcTRX1 which were treated with As2O3 for 12 h; **P < 0.01 in comparison to cells infected with AdcTRX1 and 24 h treatment with As2O3. (C) HepG2 cells infected with the different recombinant adenovirus particles were treated ...
We acknowledge that the use of SGBS (pre)adipocytes and HepG2 hepatoma cell lines constitute a simplified model of the adipose tissue–liver interaction and that these cell lines are not fully representative of adipocytes and hepatocytes in vivo. Also, although SGBS adipocytes represent a widely ...
Simplified human-derived liver models currently suffer from several limitations, yet are fundamental for the study of liver diseases, metabolic conditions and/or ADMET purposes. The most prominent underlying motor to drive hepatic dedifferentiation in healthy primary human hepatocytes (PHHs) is arguably ...
Note that other major lipid constituents (e.g., cholesterol) were not included in these simplified model bilayers. Combinations of palmitate and trehalose were introduced into the lipid bilayer systems. The structure of the molecules considered is shown in Fig. S1 in the Supplementary Material. ...