C. et al. A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies. Arch. Toxicol. 88, 1083–1095 (2014). CAS PubMed Google Scholar Bell, C. C. et al. Characterization of primary human hepatocyte ...
b. Treat cells with positive control toxins (provided) and test compounds. i. Camptothecin: 10-point dose response, Maximum final conc. = 10 µM ii. Anisomycin: 10-point dose response, Maximum final conc. = 10 µM iii. CCCP: 10-point dose response, Maximum final conc. = 100 µ...
The inhibitory effect was negatively correlated with the inoculative dose. The therapeutic effect was not improved by immediate transfection with pCH510 after chemotherapy, but was significantly improved by transfection with pCH510 5 days after chemotherapy. Chemotherapeutic agent decreased the number of ...
2K-P). The results of our study demonstrated that TB dose-dependently inhibited OA-induced ROS production in HepG2 cells (Fig. 2K-P). Exposure to OA disrupted circadian gene expression patterns in HepG2 cells, leading to alterations in the rhythmic oscillation of the Bmal1, Clock, Cry1,...
Figure 7. (a) Transmittance and (b) light output as a function of integral time measured before and after irradiation are shown for the Lu2O3:Yb ceramic sample 2 before and after the total γ-ray dose of 5.1 (red) and 10.1 Mrad (blue). Table 2 compares the scintillation performance...
This paper discusses how the assembly of pro-caspase-1 and apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC) in macromolecular protein complexes, inflammasomes, activates caspase-1. The present study investigates the m