The HepB vaccine was first licensed for use in 1981, and the following year, the CDC recommended it for high-risk groups such as health care workers, gay men, and illicit injectable drug users. It also recommended a three-dose series of the vaccine for infants born to carrier mothers star...
The vaccines are given in a series of two shots. The second is given 6-18 months after the first. The shots can be given at the same time as other vaccines. Protection from HAV starts about 2-4 weeks after the first shot. The second dose is necessary to ensure long-term (years or ...
Low-dose hyper-radiosensitivitycell cycle arrestG2/M phaseCdc25CPurpose: Although the significance of cell cycle cInternational Journal of Radiation Biology: Covering the Physical, Chemical, Biological, and Medical Effects of Ionizing and Non-ionizing Radiations...
Cells were treated with 1–3 (1.0 μM) for 24 h. The length of the tail reflects the DNA damage in cells. Full size image 1–3 Mediated S-Phase Arrest via ATM-Chk2-Cdc25A-Cdk2 and ATR-Chk1-Cdc25A-Cdk2 Pathways As known, the protein kinases ATM (ataxia-telangiectasia, mut...
Levels of total cell division cyclin 25C (Cdc25C) and phosphorylated Cdc25C were examined by Western blotting.Low-dose γ radiation (<0.3 Gy) induced HRS in HepG2 cells, while doses of 0.3, 0.5, and 2.0 Gy γ radiation significantly arrested HepG2 cells in the G2/M phase. ...
Cdc25CPurpose: Although the significance of cell cycle checkpoints in overcoming low-dose hyper-radiosensitivity (HRS) has been proposed, the underlying mechanism of HRS in human hepatocellular cells remains unclear. Therefore, the aim of this study was to characterize HRS inhuman hepatocellular HepG...
CDC-like kinase 1/CLK1 HGNC; regulation of cell cycle, cell proliferation; 4674 nucleus protein serine/threonine kinase activity; 4715 non-membrane spanning protein tyrosine kinase activity; 5524 ATP binding; 16740 transferase activity; 4672 pkinase;protein kinase activity; 3.5e-82. Pathway: ...
Introduction Acetaminophen (APAP, marketed as Paracetamol® or Tylenol®), a widely used over-the-counter analgesic and antipyretic drug, is safe and effective at therapeutic dose. However, it can cause acute liver failures such as serve hepatic necrosis, hepatic lesions and cirrhosis, and even...