Holster IL, De Maat MP, Ducharme R et al. In vitro examination of the effects of the hemostatic powder (hemospray) on coagu- lation and thrombus formation in humans. Gastrointest Endosc 2012; 75: AB240Holster IL, De Maat MP, Ducharme R, Kuiper EJ, Tjwa T. In vitro examination of the...
A typical example for this type of local hemostats is the thrombin-gelatin hemostatic matrix called Floseal, which has shown good safety and efficacy profiles in clinical studies compared to other flowable hemostats, e.g., microporous polysaccharide powder [173,174]. Floseal may be the most stu...
Massive hemorrhage following tissue trauma has high mortality owing to the lack of timely intervention. However, research on utilizing hemostats for humans is limited; therefore, developing an efficient emergency hemostatic agent is imperative. We develo
the solvent was evaporated under vacuum. The crude precipitate was dissolved in methanol and re-precipitated three times using ethyl acetate. The filter cake was then dried for 12 h at 30 °C under vacuum until NB appeared as light yellow powder (0.4 g, 1.2 mmol, 66.7%). HA...
The present invention relates to hemostatic composition comprising 1 to 90 weight percent of vitamin E or a derivative of vitamin E, 1 to 95 weight percent of oxidized cellulose, and 0.1 to 75 weight percent of water. The hemostatic composition may be formed intot pellets, powder, paste, gum...
For example, one type of prior art blood clotting material is generally a powder or a fine particulate in which the surface area of the material often produces an exothermic reaction upon the application of the material to blood. Oftentimes excess material is unnecessarily poured onto a wound, ...
which are not necessarily dependent on each other. Heparin is prepared from bovine lung tissue or porcine intestinal mucosa. Both calcium and sodium salts of heparin are available for therapeutic use and occur as a white hygroscopic powder that is easily soluble in water. It is composed of polym...
The hemostatic composition may further include fillers (e.g., aluminum sulfate) or thickening agents that facilitate the selective application of the hemostatic composition in various forms (e.g., as a paste, gel, powder, spray, aerosol, cement, or erodable (e.g., biodegradable) solid member...
, the degree of deacetylation was determined to be 67%, by the integration of the corresponding signals23, confirming an increase from the 62% measured for the native chitosan used (Supplementary Fig.2b). Powder X-ray diffraction (PXRD) data indicated the amorphous character of CDPE, and ...
In another aspect, the invention provides a method for forming a gel comprising the step of: contacting a hemostatic powder and/or aggregates composition according to the invention with blood, thereby forming a gel. In one embodiment, when the contacting is carried out with the powder composition...