The purpose of this report is to describe the clinical symptoms, laboratory profiles and family pedigree of these dogs and to discuss the role of the veterinarian in attempting to ensure that the disorder is contained by counselling owners and breeders. 展开 ...
In such case, perhaps the strain of Irish setter dogs, which appears to be deficient in the same factor as human hemophiliacs,8 could become the standard of reference for hemophilia. During the past several years, much effort in this laboratory has been devoted to developing methods for the ...
SYMPTOMSHEMOPHILIADOGSHEMORRHAGEBLOOD coagulation disordersHemophilia B is an x-linked recessive hereditary coagulopathy that has been reported in various species. We describe a male Newfoundland鈥揚arti Standard Poodle hybrid puppy and its family with hemophilia B from clinical manifestations...
The availability of animal models including FVIII and FIX-knockout mice [31–33]and hemophilia A and B dogs [34, 35]which mimic the clinical symptoms of hemophilia, will facilitate preclinical efficacy and safety studies of gene therapy strategies. Both viral vectors as well as non-viral ...
In another example, the method is a method for decreasing the symptoms associated with Gaucher disease (such as decreasing hepatosplenomegaly and improving bone marrow involvement), in a subject having Gaucher disease caused by decreased expression of acid beta-glucosidase, by orally administering a ...
Spontaneous hemarthroses were also frequent, leading to reduced locomotion and symptoms of pain in standing up, restricting nursing activity. Stronger injuries resulted in heavy bleeding and intensive pain. Laboratory tests showed increased PTT and FVIII levels (as assessed by aPTT) decreased to about...
(AAV); introduction of AAV vectors expressing factor IX into skeletal muscle or liver in hemophilic dogs has resulted in the long-term expression of factor IX at levels that are adequate to improve disease symptoms. Efforts to translate these findings into the clinical arena have proceeded slowly...
Pre-clinical studies in mice and haemophilic dogs have shown that introduction of an adeno-associated viral (AAV) vector encoding blood coagulation factor ... MA Kay,CS Manno,MV Ragni,... - 《Nature Genetics》 被引量: 1960发表: 2000年 ...
Hemophilic dogs have an identical inheritance pattern and bleeding symptoms to human hemophilia A and therefore are a most suitable animal model of the hum... JI Ori,I Tanaka,Y Kubota,... - 《Japanese Journal of Thrombosis & Hemostasis》 被引量: 4发表: 2002年 The carrier state in hemophili...