iuntseva and H erreid N ATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE EdwardDuke of Kent (1767-1820) Albert (1813-1861) Normal Male Normal Female Hemophillic MaleCarrier Female Male died in infancy possible hemophillic Alice V ictoria FrederickY Aronova...
A promoter includes necessary nucleic acid sequences near the start site of transcription, such as, in the case of a polymerase II type promoter, a TATA element. A promoter also optionally includes distal enhancer or repressor elements which can be located as much as several thousand base pairs...
The study population, recruitment processes, data collection, and analyses are described below. 2.2. Study population 2.2.1. Recruitment of HTCs HTCs from around the world are eligible to participate in the WBDR if they obtain ethics approval from their local organization. Once the HTC has obta...
Objective. We present the case of a 73-year-old female, with no family or personal history of a bleeding disorder, who had a classic presentation for acquired hemophilia A. Factor VIII activity was low but detectable and a factor VIII inhibitor was undetectable. Methods. The patient's plasma...
1. Case Presentation A 71-year-old Asian male presented to the UCSD Medical Center with generalized body bruising, intermittent gingival bleeding, hematuria, and epistaxis for one month. His medical history was remarkable for metastatic papillary thyroid cancer, which was diagnosed t...
Singleton TC, Keane M: Diagnostic and therapeutic challenges of intracranial hemor- rhage in neonates with congenital hemophilia: a case report and review. Ochsner J 12: 249, 2012. [PMID: 23049462]5. Kulkarni R, Soucie JM: Pediatric hemophilia: a review. Semin Thromb Hemost 37: 737, 2011....
1986: Carrier detection in hemophilia A: a cooperative international study. I. The carrier phenotype Blood 67(6): 1554-1559 Veltkamp, J.J. 1977: Carrier detection in hemophilia b Thrombosis and Haemostasis: 381 Graham, J.B.; Barrow, E.S.; Elston, R.C. 1973: Carrier detection in ...
A study of eight alloantibodies to FIX that developed after repeated infusions of FIX in patients with hemophilia B showed that the antibodies were immunoglobulin G (IgG), predominantly IgG subclass 1 and IgG subclass 4. They were directed against the Gla and protease domains and inhibited binding...
The mean level of factor IX in 12 carriers in this kindred was 42 per cent, with a range of 13 to 100 per cent. This patient represents the sixth reported case in which a female carrier of factor IX deficiency was symptomatic.DOI: 10.1016/0002-9343(76)90542-8 被引量: 14 ...
In this issue of JAMA, Broderick and colleagues report results of their study of the association of vigorous sports with bleeding rate in 104 children and