Hemophilia A is an X-linked recessive bleeding disorder of variable severity that is caused by a deficiency of coagulation factor VIII (FVIII). The disease results from mutations in the FVIII gene which are heterogenous both in type and position within the gene.The disease occurs almost ...
Note: Hemophilia is inherited as an X-linked recessive trait in which the mother must pass on a copy of the defective gene to a male child, and more rarely, both parents must pass on copies of the defective gene to a female child. see...
Hemophilia A is an X-linked recessive genetic bleeding disorder caused by a deficiency or functional defect in coagulation factor VIII (FVIII). There is currently no cure for hemophilia A and the mainstay of treatment is FVIII replacement therapy by infusion of plasma-derived or recombinant FVIII...
Note:Hemophilia is inherited as an X-linked recessive trait in which the mother must pass on a copy of the defective gene to a male child, and more rarely, both parents must pass on copies of the defective gene to a female child. ...
Hemophilia A genetics and inheritanceHemophilia A inheritance follows an X-linked recessive pattern. This is because the faulty F8 gene responsible for the disease is located on the X chromosome, one of the two sex-determining chromosomes in humans....
F Querol,S Pérez-Alenda,JA Aznar 摘要: Synonyms Congenital coagulopathy ; Exercise ; Factor VIII /IX deficiency Definition Hemophilia is a recessive X-linked genetic disorder. It is characterized by spontaneous hemorrhagic lesions, which can be life-threatening if not promptly and adequately treated...
he•mo•phil•i•a (ˌhi məˈfɪl i ə) n. any of severalX-linked genetic disorders, symptomatic chiefly in males, in which excessive bleeding occurs from minor injuries owing to the absence or abnormality of a clotting factor in the blood. ...
Hemophilia is an X-linked recessive disorder which is believed to affect approximately one in 5000-10.000 male birth. An inhibitor is a type of antibody. In hemophilia patients type A, B, and C are directly destroy factor VII, IX, and XI. The incidence of antibody development in hemophilia...
The biochemical derangement appears to be due to a genetically determined deficiency of a specific plasma protein, the antihemophilic factor (AHF), which is required for effective conversion of prothrombin to thrombin. Also, certain bleeders appear to have inherited as a sex-linked recessive ...
An X-linked, recessive hemorrhagic trait or gene induces Hemophilia A. Hemophilia A's X-linked trait manifests as a congenital absence or decrease in plasma clotting Factor VIII, a pro-coagulation cofactor and robust initiator of thrombin that is essential for the generation of adequate amounts ...