have a hemoglobin variant, the blood sample is subsequently reanalyzed using a high-resolution HPLC method to determine if an eluted hemoglobin species corresponds to a known hemoglobin variant by comparing the retention time of an eluted species to the retention times of known hemoglobin variants. ...
Related to Hemoglobin variants:thalassemia he·mo·glo·bin (hē′mə-glō′bĭn) n. The protein in the red blood cells of vertebrates that carries oxygen from the lungs to tissues and that consists of four polypeptide subunits, each of which is bound to an iron-containing heme molecule....
However, the presence of hemoglobin (Hb) variants may affect the measured value of Hb A1C and result in an abnormal graph trend and inconsistency between the clinical blood sugar test and Hb A1C values. In this study, laboratory data of 41,267 patients with diabetes were collected. The Hb ...
with some residue in RBC released in the second time of electrophoresis.The blood sample of β-thalassemia trait disclosed its mystery.The discovery of this phenomenon let us learn that the existing state of Hb in RBC is more complex than we expected and we believe it may have some ...
The remaining blood test results were clinically insignificant; a further review of her laboratory data over the past 4 years revealed that her fasting plasma glucose had ranged from 130 to 250 mg/dL and hemoglobin A1c was consistently lower than 5%. A study of hemoglobins detected 32.8% of ...
“pitted,” reflecting attempts by the splenic macrophages to remove the Heinz bodies. Red blood cell damage can be aggravated by the release of free heme into the red blood cell. Several biochemical perturbations correlate with the presence of free heme, such as generation of reactiveoxidants(i...
Staged diagnosis of hemoglobin variants. The complete diagnostic process includes complete blood count with red cell indices and reticulocyte counts for the classification of anemia, serum ferritin as a marker for the iron stored, and serum haptoglobin as a hemolysis marker. Most variants have a cert...
With appropriate correction, correlation of hemoglobin A1C results from the Bio-Rad Variant for individuals with D trait was good (r = 0.927). Glycohemoglobin results obtained by the two methods for some unusual structural hemoglobin variants were in close agreement. 展开 ...
The meaning of HEMOGLOBIN is an iron-containing respiratory pigment of vertebrate red blood cells that consists of a globin composed of four subunits each of which is linked to a heme molecule, that functions in oxygen transport to the tissues after conv
Disclosed is an improvement to the method of determining the concentration of a hemoglobin adduct in a blood sample by the steps of assaying the blood sample for the total amount of hemoglobin, assaying the blood sample for the hemoglobin adduct, and dividing the hemoglobin adduct concentration by...