Protein synthesis in reticulocytes depends on the availability of heme. In heme deficiency, inhibition of protein synthesis correlates with the activation of heme-regulated eIF-2alpha kinase (HRI), which blocks the initiation of protein synthesis by phosphorylating eIF-2alpha. HRI is a hemoprotein ...
Beta-thalassemia comprises two major subtypes based on the severity of the disease. Beta-globin gene mutations that negatively impact beta-globin subunit synthesis cause both. Heterozygotes with only one gene mutation have beta-thalassemia minor, which causes diminished production of beta-globin subunits...
The synthesis of HbA1C depends on the concentration of blood glucose to which the erythrocytes are exposed during their life. HbA1C represents an indicator of the average concentrations of glucose during the last 3–4 months. Glycated hemoglobin is derived from the nonenzymatic addition of glucose ...
Suppression by red blood cell synthesis by chemotherapy drugs Kidney failure Abnormal hemoglobin structure (sickle cell anemia or thalassemia) What does low hemoglobin, but normal iron levels indicate? In inflammatory conditions including certain chronic diseases, there may be a normal or sometimes increa...
HEMOGLOBIN Usage And Synthesis DescriptionHaemoglobin, the oxygen-transport protein in the red blood cells, is a tetramer and each of the four chains contains a haeme group. It is interesting to note that the four haeme groups in haemoglobin do not operate independently. The release (and bindin...
Suppression by red blood cell synthesis by chemotherapy drugs Kidney failure Abnormal hemoglobin structure (sickle cell anemia or thalassemia) What does low hemoglobin, but normal iron levels indicate? In inflammatory conditions including certain chronic diseases, there may be a normal or sometimes increa...
Synthesis of β-globin may vary from near complete to absent, causing β-thalassemia of various degrees of severity due to mutation of genes (one gene each on chromosome 11); more than 200 point mutations have been reported. However, deletion of both genes is rare. β-Thalassemia can be ...
Synthesis, physico-chemical and biological properties of crosslinked modified hemoglobin.AnimalsDogsHumansRatsErythrocytesOxygenPyridoxal PhosphateOxyhemoglobinsBlood SubstitutesElectrochemistryPolymer aspects of polycondensation of pyridoxylated with glutaraldehyde have been considered. On the basis of the investigation...
GLYCATED HEMOGLOBIN STRUCTURE AND SYNTHESIS OF MOLECULE: Glycated hemoglobin A1c, the major fraction of glycated hemoglobin, is formed by irreversible nonenzymatic glycation. Its concentration depends only on the life span of red blood cells and blood glucose levels. CLINICAL SIGNIFICANCE OF GLYCATED HEMO...
Segmental duplications involving the α-like globin gene cluster on chromosome 16, result in increased copy number of α globin genes, is another mechanisms that cause an imbalance between the α and β chain ratio. The underlying reason for this imbalance is the increased α chain synthesis....