O. Poyton, "Yeast flavohemoglobin, a nitric oxide oxidore- ductase, is located in both the cytosol and the mitochondrial matrix: effects of respiration, anoxia, and the mitochondrial genome on its intracellular level and distribution," Journal of Biological Chemistry, vol. 280, no. 9, pp. ...
This suggests either that YHb cannot be reduced in vivo or that YHb heme is maintained in an oxidized state in respiring cells. By using an anti-YHb antibody and CO difference spectroscopy and by measuring NO consumption, we have found that YHb localizes to two distinct intracellular ...
Site-directed mutagenesis in hemoglobin: test of functional homology of the F9 amino acid residues of hemoglobin α and β chains The cysteine residue at F9(93) of the human hemoglobin (Hb A) β chain, conserved in mammalian and avian hemoglobins, is located near the functionally impo... ...
a swollen mass of veins located at or just within the anus plural the condition of a person who has hemorrhoids called alsopiles hemorrhoidnoun a swollen mass of veins located at or just within the anus plural the condition of a person who has hemorrhoids called alsopiles ...
The current model for oxygen binding in haemoglobin and myoglobin can be explained in the following way. The deoxy form contains a high-spin Fe(II) centre, which, because of its size, does not form a plane with its four nitrogen donor atoms. Instead, it is located slightly above the plan...
Hemoglobin is a tetrameric protein, with two α and two β globin chains each, which are bound ionically, non-covalently to hydrophobic contact regions and the heme group, which consists of a porphyrin ring with a central iron atom for oxygen affinity. The heme group is located in a V-sh...
Genetic coding for the alpha chains is stored in four codominant alleles paired on chromosome 16. The nonalpha chains are coded by two codominant alleles located in a cluster of beta-genes on chromosome 11, the various genes within this cluster coding for different non-alpha chains. The four ...
These Trp residues are located in important regions of the Hb molecule, i.e. α14Trp and β15Trp are located in the α 1β 1 subunit interface and β37Trp is located in the α 1β 2 subunit interface. The relaxation experiments show that amino acid substitutions in the α 1β 2 ...
In contrast, nonvolatile cues are detected by vomeronasal receptors in the vomeronasal organ (VNO) located beneath the nasal cavity, and usually convey sociosexual information associated with stereotypical behavior or emotional changes6,7. Secretions, such as urine, tear fluid, and saliva contain ...
(Weinberg, 1984, Physiological. Rev. 64: 65-102), because iron is a necessary nutrient for most microbial pathogens. The vast majority of iron in the human adult is located intracellularly in the form of haemoglobin (76%) or ferritin (23%). The remainder can be found extracellularly bound...