Related to Hemoglobin, sickle: sickle cell trait, sickle cell anemia, sickle cell diseaseThesaurusAntonymsRelated WordsSynonymsLegend: Switch to new thesaurus Noun 1. sickle-cell disease - a congenital form of anemia occurring mostly in blacks; characterized by abnormal blood cells having a crescent...
We tested the hypothesis that sickle cell trait or hemoglobin C trait is an independent risk factor for invasive pneumococcal disease. Method: Eligible children were born in Tennessee (1996-2003), had a newborn screen, enrolled in TennCare aged <1 year, and resided in a Tennessee county ...
A fast hemoglobin variant on newborn screening is associated with alpha-thalassemia trait. Clin Pediatr. (Phila) 1997;36(2):75-78.Miller ST, Desai N, Pass KA, et al. A fast hemoglo- bin variant in newborn screening is associated with α-thalassemia trait. Clin Pediatr 1997;36:75-8....
Data from state newborn screening programs in 2010 showed that 1.5% of all infants screened had sickle cell trait.21 The incidence of sickle cell trait varies among different races and ethnicities; African American infants have the highest incidence at 73.1 cases per 1000 births, compared with ...
Complete blood count (CBC) and high performance liquid chromatography (HPLC) were used to screen for thalassemia and hemoglobinopathies. Patients were diagnosed as having thalassemia trait if the mean corpuscular volume (MCV) was ¤80.0 fL, mean corpuscular hemoglobin (Hb) was ¤27.0 pg and Hb ...
Genetic counseling following the detection of hemoglobinopathy trait on the newborn screen is well received, improves knowledge, and relieves anxiety The primary purpose of newborn screening for hemoglobinopathies is the presymptomatic diagnosis and early treatment of sickle cell disease. Hemoglobinopath....
The significance of the paucity of sickle cells in newborn Negro infants Am. J. Med. Sci., 215 (1948), pp. 419-423 CrossrefView in ScopusGoogle Scholar 4 G.F. Jacob, A.B. Raper Hereditary persistence of foetal haemoglobin production, and its interaction with the sickle-cell trait Br....
There is no difference of awareness in different age groups, either, given that hemoglobin variants are included in the Newborn Screen Program in most states. One patient, at age 55, with hemoglobin C disease (HbCC) was undiagnosed. CONCLUSIONS. Although most patients who are carriers of ...
Barts Hgb (γ4) can be seen in the newborn period, and may be picked up on the newborn screen. These patients will have a varying degree of microcytic, hypochromic anemia and splenomegaly. The anemia can be severe and can be exacerbated by stress (such as infection or pregnancy). An ...
Genome-wide association studies (GWAS) confirm the polygenic nature of the trait by showing hundreds of common variants associated with height. The loci in the ZBTB38 (zinc finger and BTB domain-containing 38) gene are considered the most frequently associated with height in GWAS [8,9]. The ...