The genetic status of 1 patient is indeterminate, and 1 patient with normal hepatic iron concentration and hepatic iron index had chronic active hepatitis. None had cirrhosis, diabetes, or cardiomyopathy. No patients with hemochromatosis would have been detected without this study. CONCLUSIONS: The ...
A significant body of research over the last 10-20 years supports the hypothesis that screening for hereditary hemochromatosis (HH) may be cost-effective, ... GJ Buffone,JR Beck - 《Clinical Chemistry》 被引量: 103发表: 1994年 Genetic testing in the European Union: does economic evaluation ...
than not screening, it is associated with the increase of 7 years in the life expectancy of individuals identified with HH-HFE and treated.51 In this analysis, genetic testing was found to be the most cost effective as the final confirmatory test, rather than as the initial screening test. ...
reported that the geno- typic screening of voluntary blood donors and their siblings by genotyping would be less expensive than phenotypic screening with biochemical tests if the genetic test cost less than $28. However, if the genetic test cost $173, then it would cost nearly $110,000 to ...
Hereditary Hemochromatosis is the most prevalent hereditary genetic disease in Northern Europe, the US and Australia, affecting more than 5 million people. HH is also known as The Celtic Curse, as upto 1 in 5 people of Celtic origin carry at least one faulty gene! Patients have to be monitor...
HFE Test.A HFE test is a genetic test for the presence of either of the two main mutations (C282Y and H63D) of the HFE gene. These mutations are the most common causes of hereditary hemochromatosis. An individual with Type I hemochromatosis generally carries two copies of the C282Y gene,...
Cost-effectiveness of genetic diagnosis for Hereditary Hemochromatosis screeningdoi:10.1016/S0016-5085(00)81504-8PardoAlbertoElsevier Inc.Gastroenterology
Background: A genetic test for hemochromatosis has allowed for the first time, genotypic identification of heterozygotes. The purpose of this study is to d... Paul,C,Adams - 《Clinical Genetics》 被引量: 190发表: 1998年 The Cost-Effectiveness of Screening for Hereditary Hemochromatosis in Germa...
Scho¨ffski O, Schmidtke J, Stuhrmann M: Cost-effectiveness of population-based genetic hemochromatosis screening. Community Genet 2000; 3: 2 - 11.Scho¨ ffski O, Schmidtke J, Stuhrmann M. Cost-effectiveness of population-based genetic hemochromatosis screening. Commu- nity Genetics. 2000;3:...
There Should be a Suitable Test or Examination. Serum transferrin saturation, ferritin, and liver biopsy with quantitative iron analysis have previously been the standard of care for the diagnosis of hemochromatosis. In the future, genetic testing for the C282Y mutation of the HFE gene will likely...