820 Heme is released from red blood cells and hemoproteins during several pathological states, including bacterial infections, ischemia-reperfusion and hemolytic anemias. An excess of free heme is toxic, causing oxidative stress that activates endothelial cells and the inflammatory response. Heme has ...
haemoglobin,Hb,hemoglobin- a hemoprotein composed of globin and heme that gives red blood cells their characteristic color; function primarily to transport oxygen from the lungs to the body tissues; "fish have simpler hemoglobin than mammals" ...
It is further conceivable that excess use of red blood cell transfusion is associated with increased incidence of AKI and mortality (91) because of increased iron toxicity. Therefore, it is possible that CPB-induced AKI may be at least in part a renal sideropathy with free iron as the ...
14. The focus of current research also focuses on heme decomposition products of cell protective effect. 目前研究的焦点也主要集中于血红素分解产物的细胞保护作用。 15. Hemoglobin is the major heme protein of red blood cells and is responsible for the transport of oxyge... ...
Red blood cell hemolysis in sickle cell disease (SCD) releases free hemoglobin. Extracellular hemoglobin and its degradation products, free heme and iron, are highly toxic due to oxidative stress induction and decrease in nitric oxide availability. We propose an approach that helps to eliminate extra...
Hemoglobin (Hb) is a protein with a labile heme prosthetic group, found in red blood cells (RBCs) that carries oxygen throughout the body. When released from the RBCs, cell-free hemoglobin and resulting cell-free heme can lead to heme toxicity, which is regarded as both one of the ...
In this report, we discuss the evidence for the staging of red blood cell removal after ICH and the significance of control of this process. The protective effects of clinically relevant metalloporphyrin heme oxygenase inhibitors in experimental models of ICH and in superficial siderosis are also ...
n.a complex red organic pigment containing iron and other atoms to which oxygen binds heme词组 heme oxygenase血红素氧化酶;血红素加氧酶 heme_体育行业词汇 血红素 heme_医学行业词汇 血红素:铁与卟啉上4个吡咯基的配位蝥合物,进一步再由蝥合的铁是Fe(Ⅱ)还是Fe(Ⅲ)而区别为〔亚铁〕血红素和高铁血红素。4...
Ferrous human serum heme-albumin (HSA-heme-Fe(II)) binds reversibly to NO and CO. Although the heme-Fe atom of HSA-heme-Fe(II) is rapidly oxidized by O2, HSA-heme-Fe(II) mutants bearing residues pivotal for O2recognition have been proposed not only as red blood cell substitutes, but ...
Red blood cells were lysed with 0.05% saponin followed by multiple washes with PBS to remove traces of hemoglobin. The pellet was then resuspended in PBS and cell number quantified by flow cytometry. The remaining parasites were then lysed using hypotonic stress and sonication. Following ...