Heme oxygenase-1 (HO-1) is a rate-limiting enzyme catalyzing oxidative degradation of cellular heme to liberate free iron, carbon monoxide (CO) and biliverdin in mammalian cells. In addition to its primary role in heme catabolism, HO-1 exhibits anti-oxidative and anti-inflammatory functions via...
Heme-oxygenase-1 (HO-1) is the inducible rate-limiting enzyme involved in the catabolism of free heme. It participates in several processes, by providing cytoprotection, protecting from heme-induced toxicity, and regulating the host inflammatory response [14,17]. In fact, HO-1 acts as a stres...
Hemeoxygenase‐1 (HO‐1) is increased in psoriatic skin. We asked for the impact of physiological and pharmacological HO‐1 induction on skin immunity and the mechanisms involved in HO‐1‐induced immunomodulation. We found cutaneous HO‐1 expression upregulated comparable with suppressors of cytokin...
The low-molecular-weight stress protein heme oxygenase-1 (HO-1) confers cytoprotection against cell death in various models of lung and vascular injury by inhibiting apoptosis, inflammation, and cell proliferation. HO-1 serves a vital metabolic function as the rate-limiting step in the heme ...
Heme oxygenase-1 (HO-1) has been implicated in cardiac dysfunction, oxidative stress, inflammation, apoptosis and autophagy associated with heart failure, and atherosclerosis, in addition to its recognized role in metabolic syndrome and diabetes. Numerous studies have presented contradictory findings about...
Heme oxygenase-1 Heme Replication stress G-quadruplexes PARP1 Cell cycle 1. Introduction Heme oxygenase-1 (HO-1, encoded by the HMOX1 gene) is an inducible enzyme that plays a central role in heme catabolism. HO-1 converts heme to biliverdin, carbon monoxide (CO), and iron ion. Due ...
HEME OXYGENASE-1DENDRITIC CELLSINTESTINAL INFLAMMATIONThe function of regulatory T cells (T(reg) cells) has been attributed to a growing number of diverse ... Q Tang,JA Bluestone - 《Nature Immunology》 被引量: 1659发表: 2008年 Suppression by CD4+CD25+ regulatory T cells is dependent on expr...
Background Heme oxygenase-1 (HO-1) can be induced by inflammatory cytokines, oxidation, ischemia, hypoxia, and endotoxins. As a "graft survival protective gene," HO-1 is a hot spot in organ transplantation research. However, the role of HO-1 gene expression in the function of human colon...
Once in the microglia, heme induces the transcription of HO-1. Heme oxygenase 1 then metabolizes heme to biliverdin, CO and iron (Fig. 2). The iron released by HO-1 is bound by ferritin, perhaps via a HO-1 chaperone function69. Overproduction of HO-1 protects vessels against heme and...
(redirected fromHeme oxygenase) Thesaurus Medical Acronyms Encyclopedia Wikipedia Ho1 The symbol forholmium. Ho2 abbr. BibleHosea ho1 (hō) interj. Used to express surprise or joy, to attract attention to something sighted, or to urge onward:Land ho! Westward ho!